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Comparative genomics analysis of Mycoplasma capricolum subsp. capripneumoniae 87001. Genomics. 2019 May 6. pii: S0888-7543(19)30138-7

YuanLi ,RuiWang ,WenjingSun ,ZhiqiangSong ,FanBai ,HuajunZheng,JiuqingXin.

 

Genomics. 2019 May 6. pii: S0888-7543(19)30138-7. doi: 10.1016/j.ygeno.2019.04.013

 

Abstract

Mycoplasma capricolum subsp. capripneumoniae (Mccp), belongs to Mycoplasma mycoides cluster and is a causal pathogen of contagious caprine pleuropneumonia (CCPP). This paper presents the complete annotated genome sequence of Mccp Strain 87001-a strain that was isolated from pneumonia affected goats on a farm in China, and comparative genomics analysis of five Mccp genomes in addition to comparative genomics within Mycoplasma mycoides cluster. The Mccp strain 87001 genome consists of a single circular chromosome 1017333 bp in length and encodes 898 open reading frames (orfs) averaging 944 bp in length. Fifty eight potential virulence genes were identified, including variable surface lipoproteins, hemolysin A, and P60 surface lipoprotein. Comparative genomic analysis revealed eight virulence genes and four extracellular genes which remained unchanged in five Mccp genomes for forty years, which can be used as potential target for drug development and vaccine design. We revealed 183 Mccp unique genes as markers to distinguish Mccp with other mycoplasma strains from goats, and different virulence factors contributing to host specificity and different syndrome of bovine pathogens and caprine pathogens.

Copyright © 2018. Published by Elsevier Inc.

 

KEYWORDS:

Contagious caprine pleuropneumonia (CCPP); Genome; Mycoplasma capricolum subsp. capripneumoniae (Mccp); Virulence factor

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