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国家优秀青年科学基金获得者

王晓钧

 
王晓钧 博士,研究员,博士生导师,中共党员

职务:中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室副主任;大动物病研究室副主任;马传染病与慢病毒病研究创新团队首席科学家

单位:中国农业科学院哈尔滨兽医研究所

地址:黑龙江省哈尔滨市南岗区哈平路678号,邮编150069

电话:0451-51051749(办公室)

手机:wangxiaojun@caas.cn

 

教育背景:

 

1992-1996内蒙古民族大学,兽医系,学士

1996-1999中国农业科学院研究生院,中国农业科学院哈尔滨兽医研究所 硕士

2000-2003中国农业科学院研究生院,中国农业科学院哈尔滨兽医研究所 博士

 

工作经历:

 

1999-2005  中国农业科学院哈尔滨兽医研究所,研究实习员,助理研究员,课题主持人

2005-2010  美国密西根州立大学微生物与分子遗传学系,博士后研究员

2010 至今    中国农业科学院哈尔滨兽医研究所,研究员,研究室副主任,马病研究首席专家,哈尔滨兽医研究所学术委员会委员

 

获奖情况:


1. 哈尔滨市青年科技奖,2016年
2. 中国畜牧兽医学会马学分会“2016全国马业科技十大先进工作者”
3. 中国农业科学院2014-2015年度先进工作者
4. 中国马业协会“2015年度杰出马兽医”
5. 中国农业科学院金龙鱼杰出青年奖,2014年
6. 首届国家国家自然基金委优秀青年基金获得者,2012年
7. 中国马流感病毒分离株分离鉴定及病毒进化的研究,中国农科院科技成果奖, 二等奖,2011-2-10-04,2011年,第四名
8. 无规定马属动物疫病区模式建立与应用研究, 广州市科技进步奖,一等奖,  2012年,第十名
9. 我国马流感病毒不同分离株生物学特征的研究,中国农科院科技进步二等奖,2004年(第四名)
10. 我国马流感病毒不同分离株生物学特征的研究,哈尔滨市科技进步三等奖2004年(第四名)

 

专著:

 

1. 马流感,学术专著,动物疫病防控出版工程,中国农业出版社,ISBN:9787109210158,230千字,2015年12月出版。
2. 马传染性贫血,学术专著,动物疫病防控出版工程,中国农业出版社,ISBN:9787109206618,200千字,2015年12月出版。
3. 默克兽医手册,学术专著,动物疫病防控出版工程,中国农业出版社,ISBN:9787109207509,4112千字,2015年12月出版。
4. 现代动物病毒学,学术专著,中国农业出版社,ISBN:9787109197435,2783千字,2014年12月出版。
5. 动物病毒反向遗传学,学术专著,生命科学专论,科学出版社,ISBN:9787030420718,883千字,2009年2月出版。

 

专利:

 

1. 王晓钧,胡哲。一种可抑制病毒粒子释放的蛋白,其编码序列及在抑制EIAV从细胞释放中的应用,2014年9月,中国,ZL201210535066.1。
2. 王晓钧,胡哲。一种用于检测I型和IV型马疱疹病毒的双重EvaGreen实时荧光定量PCR检测试剂盒及其应用。2014年9月,中国,ZL201410042034.7。
3. 王晓钧,胡哲,林跃智,周建华。用于检测马传染性贫血病毒p26蛋白的试剂盒及其用途。2014年5月,中国,ZL201410239152.7。
4. 王晓钧。分泌SAMHD1蛋白单克隆抗体的杂交瘤细胞株、由该细胞株分泌的单克隆抗体及应用。2012年12月,中国,ZL201210535066.1。
5. 马传染性贫血病毒代表毒株的全基因克隆极其应用。1999年12月,ZL99127532.2。

 

主要学术兼职:

 

1. 中国微生物学会病毒学委员会青年病毒学委员会 副主任委员(2013- )
2. 世界卫生组织OIE 马流感监测专家组(ESP)成员(2011-  )
3. 世界卫生组织OIE专家 OIE马传染性贫血参考实验室主任(2014- )
4. 中国马业协会,理事(2014-)
5. 中国畜牧兽医学会马学分会,副理事长(2014-)
6. 全国动物卫生标准委员会,委员(2014-)

 

承担主要科研项目:

 

起止时间

项目来源及经费

项目名称

排序

2018/06-2021/06

“十三五” 国家重点研发计划项目课题(2018YFD0502205)359

驴规模化养殖疫病防控技术与快繁技术的集成与示范

主持

2018/01-2021/12

黑龙江省自然科学基金杰出青年项目(JC2018010)50万

宿主抗逆转录病毒限制因子发掘及其机制研究

主持

2016/01-2018/12

国家自然基金国际合作重点项目(81561128010300

对巨噬细胞HIV病毒储库的清除策略研究

主持

2016/01-2021/12

国家自然基金创新研究群体项目(315210051200

动物流感病毒的进化及其与宿主互作机制

 

参加

2014/11-2017/12

科技部援外项目(KY201401006

540万元

中哈农业科学联合实验室及教学示范基地

主持

2013/01-2015/12

国家优秀青年基金(31222054

100万元

抗逆转录病毒天然免疫

主持

2011/01-2013

国家自然基金面上项目(31072133

34万元

马天然免疫限制因子对逆转录病毒的抑制作用及机理

主持

2002/012005

国家自然科学基金青年基金项目(3020020020万元

马传贫病毒基因非编码区LTR与毒力致弱的相关性

主持

2011/01-2013

国际动物卫生组织(OIE)参考实验室项目  13万欧元

马流感OIE参考实验室协作(twinning)项目

主持

2010/01-2011

兽医生物技术国家重点实验室自主课题

50万元

EIAV疫苗致弱过程中宿主限制性因子的作用

主持

2006/09-2011/09

美国NIH(RO1)

1650000美元

Actions of VIF and Apobec3 Proteins in HIV-1 Replication AI063944

参加

2008-2011

美国NIH

409588美元

ARRA Administrative Supplements

参加

2008-2013

美国NIH

522398美元

Mechanism of APOBEC3mediated innate immunity

参加

2000/012002

黑龙江省自然科学基金

9万元

我国马流感病毒血凝素基因分子进化树的构建

主持

2000/012005

科技部基础研究重大项目前期研究专项

30万元

以马传染性贫血病毒疫苗为基础的新型艾滋病疫苗发展策略

参加

 


发表文章:

 

1. Wang Y, Zhang H, Na L, Du C, Zhang Z, Zheng Y, Wang X*(2019) ANP32A and ANP32B are key factors in the Rev dependent CRM1 pathway for nuclear export of HIV-1 unspliced mRNA. J Biol Chem, 2019 Aug 23, doi: 10.1074/jbc.RA119.008450 jbc.RA119.008450.

2. Du C, Duan Y, Wang X, Lin Y, Na L, Wang X, Chen K, Wang X*. Attenuation of equine lentivirus alters mitochondrial protein expression profile from inflammation to apoptosis. J Virol. 2019 Aug 7. pii: JVI.00653-19. doi: 10.1128/JVI.00653-19. [Epub ahead of print] PubMed PMID: 31391270.

3.Wang XF, Bai B, Lin Y, Qi T, Du C, Song M*, Wang X. High-Efficiency Rescue of Equine Infectious Anemia Virus from a CMV-Driven Infectious Clone. Virol Sin. 2019 Aug 2. doi: 10.1007/s12250-019-00153-w. [Epub ahead of print] PubMed PMID: 31376080.

4. Liu C, Wang XF, Wang Y, Chen J, Zhong Z, Lin Y*, Wang X*. Characterization of EIAV env Quasispecies during Long-Term Passage In Vitro: Gradual Loss of Pathogenicity. Viruses. 2019 Apr 24;11(4). pii: E380. doi: 10.3390/v11040380. PubMed PMID: 31022927; PubMed Central PMCID: PMC6520696.

5. Miño S, Mojsiejczuk L, Guo W, Zhang H, Qi T, Du C, Zhang X, Wang J, Campos R, Wang X*. Equine Influenza Virus in Asia: Phylogeographic Pattern and Molecular Features Reveal Circulation of an Autochthonous Lineage. J Virol. 2019 Jun 14;93(13). pii: e00116-19. doi: 10.1128/JVI.00116-19. Print 2019 Jul 1. PubMed PMID: 31019053; PubMed Central PMCID: PMC6580976.

6. Zhang H, Zhang Z, Wang Y, Wang M, Wang X, Zhang X, Ji S, Du C, Chen H, Wang X*. Fundamental contribution and host range determination of ANP32A and ANP32B ininfluenza A virus polymerase activity. J Virol. 2019 Apr 17. pii: JVI.00174-19. doi: 10.1128/JVI.00174-19. [Epub ahead of print] PubMed PMID: 30996088.

7. Wang M.; Zhang Z.; Wang X*. Strain-Specific Antagonism of the Human H1N1 Influenza A Virus against Equine Tetherin. Viruses 2018, 10, 264.

8. Ji S, Na L, Ren H, Wang Y, Wang X*, Equine Myxovirus Resistance Protein 2 Restricts Lentiviral Replication by Blocking Nuclear Uptake of Capsid Protein[J]. Journal of Virology, 2018:JVI.00499-18.

9. Wang XF, Liu Q, Wang YH, Wang S, Chen J, Lin YZ, Ma J, Zhou JH, Wang X*. Characterization of EIAV LTR quasispecies in vitro and in vivo. J Virol. 2018 Jan 31. pii: JVI.02150-17. doi: 10.1128/JVI.02150-17. [Epub ahead of print] PubMed PMID: 29386282.

10. Na L, Tang YD, Wang C, Liu C, Wang X*. Rhesus monkey TRIM5alpha SPRY domain contributes to AP-1 activation. J Biol Chem. 2017 Dec 1. pii: jbc.RA117.000127.doi: 10.1074/jbc.RA117.000127. [Epub ahead of print] PubMed PMID: 29196608.

11. Liu Q, Wang XF, Du C, Lin YZ, Ma J, Wang YH, Zhou JH, Wang X*. The integration of a macrophage-adapted live vaccine strain of equine infectious anemia virus (EIAV) in the horse genome. J Gen Virol. 2017 Sep 7. doi: 10.1099/jgv.0.000918. [Epub ahead of print]

12. Qi T, Wang X*. Optimization and application of a DNA-launched infectious clone of equine arteritis virus. Appl Microbiol Biotechnol. 2017 Nov 13. doi: 10.1007/s00253-017-8610-0. [Epub ahead of print]

13. Du C, Hu Z, Hu SD, Lin YZ, Wang X*, Li YJ*. Development and application of an indirect ELISA for the detection of gp45 antibodies to equine infectious anemia virus. J Equine Vet Sci. 2017 doi: 10.1016/j.jevs. 2017.10.018.[Epub ahead of print]

14. Ai YW*, Ma JZ*, Wang X*. Clues for two-step virion infectivity factor regulation by core binding factor beta. J Gen Virol. 2017 May;98(5):1113-1121.

15. Yao Q, Ma J, Wang X, Guo M, Li Y*, Wang X*. A pilot study on interaction between donkey tetherin and EIAV stains with different virulent and replication characteristics. Microb Pathog. 2016 Nov 2. pii: S0882-4010(16)30300-X. 

16. Hu Z, Chang HChu XLi S, Wang M, Wang X*, Identification and characterization of a common B-cell epitope on EIAV capsid proteins, Appl Microbiol  Biotechnol. 2016, Dec;100(24):10531-10542.

17. Ma J, Zhang Z, Yao Q, Su C, Yin X, Wang X*,Regulation of Rev expression by the EIAV tat-rev mRNA Kozak sequence and its potential influence on viral replication. J Gen Virol. 2016 Jul 13. doi: 10.1099/jgv.0.000548. [Epub ahead of print] PubMed PMID: 27411804.

18. Lin YZ, Sun LK, Zhu DT, Hu Z, Wang XF, Du C, Wang YH, Wang X*, Zhou JH*. Equine schlafen 11 restricts the production of equine infectious anemia virus via a codon usage-dependent mechanism. Virology. 2016 May 17;495:112-121. doi:10.1016/j.virol.2016.04.024. [Epub ahead of print] PubMed PMID: 27200480.

19. Wang XF, Lin YZ, Li Q, Liu Q, Zhao WW, Du C, Chen J, Wang X*, Zhou JH*. Genetic Evolution during the development of an attenuated EIAV vaccine. Retrovirology. 2016 Feb 3;13(1):9. doi: 10.1186/s12977-016-0240-6. PMID: 26842878 Free PMC Article

20. Duan L, Du J, Wang X, Zhou J, Wang X, Liu X*. Structural and functional characterization of EIAV gp45 fusion peptide proximal region and asparagine-rich layer. Virology. 2016 Feb 11;491:64-72. doi: 10.1016/j.virol.2016.01.010. [Epub ahead of print] PMID: 26874586

21. Liu Q, Ma J, Wang XF, Xiao F, Li LJ, Zhang JE, Lin YZ, Du C, He XJ, Wang X*, Zhou JH*. Infection with equine infectious anemia virus vaccine strain EIAVDLV121 causes no visible histopathological lesions in target organs in association with restricted viral replication and unique cytokine response. Vet Immunol Immunopathol. 2016 Feb;170:30-40. doi: 10.1016/j.vetimm.2016.01.006. Epub 2016 Jan 23. PMID: 26832985

22. Zhang Z, Ma J, Zhang X, Su C, Yao QC, Wang X*. Equine Infectious Anemia Virus Gag Assembly and Export Are Directed by Matrix Protein through trans-Golgi Networks and Cellular Vesicles. J Virol. 2015 Dec 4;90(4):1824-38. doi: 10.1128/JVI.02814-15. PMID: 26637458

23. Huang L, Liu Q, Zhang L, Zhang Q, Hu L, Li C, Wang S, Li J, Zhang Y, Yu H, Wang Y, Zhong Z, Xiong T, Xia X, Wang X, Yu L, Deng G, Cai X, Cui S, Weng C*. Encephalomyocarditis Virus 3C Protease Relieves TRAF Family Member-associated NF-κB Activator (TANK) Inhibitory Effect on TRAF6-mediated NF-κB Signaling through Cleavage of TANK. J Biol Chem. 2015 Nov 13;290(46):27618-32. doi: 10.1074/jbc.M115.660761. Epub 2015 Sep 11. PMID: 26363073

24. Liu Q, Wang XF, Ma J, He XJ, Wang X* & Zhou JH*. Characterization of Equine Infectious Anemia Virus Integration in the Horse Genome.[J]. Viruses, 2015, 7(6):3241-3260.

25. Ma Y, Liu D, Gao J, Wang X*. Similar regulation of two distinct UL24 promoters by regulatory proteins of equine herpesvirus type 1 (EHV-1). FEBS Lett. 2015 Jun 4;589(13):1467-75. doi: 10.1016/j.febslet.2015.04.039.  Epub 2015 May 1. PMID: 25937123

26. Du C, Ma J, Liu Q, Li YF, He XJ, Lin YZ, Wang XF, Meng QW, Wang X*, Zhou JH*. Mice transgenic for equine cyclin T1 and ELR1 are susceptible to equine infectious anemia virus infection. Retrovirology. 2015 Apr 28;12:36. doi: 10.1186/s12977-015-0163-7. PMID: 25928027 Free PMC Article

27. Du C, Liu H, Lin Y, Wang X, Ma J, Li Y, Wang X*, Zhou J*. Proteomic alteration of equine monocyte-derived macrophages infected with equine infectious anemia virus. Proteomics, 2015, online. DOI: 10.1002/pmic.201400279

28. Tang YD, Na L, Fu LH, Yang F, Zhu CH, Tang L, Li Q, Wang JY, Li Z, Wang XF, Li CY, Wang X*, Zhou JH*. Double-stranded RNA-specific adenosine deaminase 1 (ADAR1) promotes EIAV replication and infectivity. Virology. 2015 Jan 9;476C:364-371. doi: 10.1016/j.virol.2014.12.038. [Epub ahead of print] PubMed PMID: 25589239.

29. Wang XF, Wang S, Liu Q, Lin YZ, Du C, Tang YD, Na L, Wang X*, Zhou JH*. A unique evolution of the s2 gene of equine infectious anemia virus in hosts correlated with particular infection statuses. Viruses. 2014 Nov 10;6(11):4265-79. doi: 10.3390/v6114265. PubMed PMID: 25390683.

30. Hu Z, Chang H, Ge M, Lin Y, Wang X, Guo W, Wang X*. Development of antigen capture ELISA for the quantification of EIAV p26 protein. Appl Microbiol Biotechnol. 2014 Nov;98(21):9073-81. doi: 10.1007/s00253-014-6078-8. Epub 2014 Sep 26. PubMed PMID: 25256618.

31. Tang YD, Na L, Zhu CH, Shen N, Yang F, Fu XQ, Wang YH, Fu LH, Wang JY, Lin YZ, Wang XF, Wang X, Zhou JH, Li CY. Equine Viperin Restricts Equine Infectious Anemia Virus Replication by Inhibiting the Production and/or Release of Viral Gag, Env, and Receptor via Distortion of the Endoplasmic Reticulum. J Virol. 2014 Nov 1;88(21):12296-310. doi: 10.1128/JVI.01379-14. Epub 2014 Aug 13. PubMed PMID: 25122784.

32. Ai Y, Zhu D, Wang C, Su C, Ma J, Ma J*, Wang X*. Core-binding factor subunit beta is not required for non-primate lentiviral Vif-mediated APOBEC3 degradation. J Virol. 2014 Oct;88(20):12112-22. doi: 10.1128/JVI.01924-14. Epub 2014 Aug 13. PubMed PMID: 25122780;

33. Ma J, Wang SS, Lin YZ, Liu HF, Liu Q, Wei HM, Wang XF, Wang YH, Du C, Kong XG, Zhou JH*, Wang X*. Infection of equine monocyte-derived macrophages with an attenuated equine infectious anemia virus (EIAV) strain induces a strong resistance to the infection by a virulent EIAV strain. Vet Res. 2014 Aug 9;45:82. doi: 10.1186/PREACCEPT-1630367192112621. PubMed PMID: 25106750.

34. Hu Z, Zhu C, Chang H, Guo W, Liu D, Xiang W, Wang X*. Development of a single-tube duplex EvaGreen real-time PCR for the detection and identification of EHV-1 and EHV-4. Appl Microbiol Biotechnol. 2014 May;98(9):4179-86. doi: 10.1007/s00253-014-5626-6. Epub 2014 Mar 11. PubMed PMID: 24615388.

35. Na L, Tang YD, Liu JD, Yu CQ, Sun LK, Lin YZ, Wang XF, Wang X*, Zhou JH*. TRIMe7-CypA, an alternative splicing isoform of TRIMCyp in rhesus macaque negatively modulates TRIM5α activity. Biochem Biophys Res Commun. 2014 Apr 4;446(2):470-4. doi: 10.1016/j.bbrc.2014.02.132. Epub 2014 Mar 12. PubMed PMID: 24613845.

36. Wang M, Guo W, Igarashi I, Xuan X, Wang X, Xiang W, Jia H. Epidemiological investigation of equine piroplasmosis in China by enzyme-linked immunosorbent assays. J Vet Med Sci. 2014 Apr;76(4):549-52.

37. Yin X, Lin Y, Cai W, Wei P, Wang X*. Comprehensive analysis of the overall codon usage patterns in equine infectious anemia virus. Virol J. 2013 Dec 20;10:356. doi: 10.1186/1743-422X-10-356. PubMed PMID: 24359511; PubMed Central PMCID: PMC3878193.

38. Yin X, Hu Z, Gu Q, Wu X, Zheng YH, Wei P, Wang X*. Equine tetherin blocks retrovirus release and its activity is antagonized by equine infectious anemia virus envelope protein. J Virol. 2014 Jan;88(2):1259-70. doi: 10.1128/JVI.03148-13. Epub 2013 Nov 13. PubMed PMID: 24227834;

39. Hu Z, Wu X, Ge J, Wang X*. Inhibition of virus replication and induction of human tetherin gene expression by equine IFN-α1. Vet Immunol Immunopathol. 2013 Nov 15;156(1-2):107-13. doi: 10.1016/j.vetimm.2013.09.009. Epub 2013 Sep 20. PubMed PMID: 24144682.

40.Wang Q, Ji X, Gao Y, Qi X, Wang X, Wang Y, Qin L, Gao H, Wang X*. Overexpression of microRNA gga-miR-1650 decreases the replication of avian leukosis virus subgroup J in infected cells. J Gen Virol. 2013 Oct;94(Pt 10):2287-96. doi: 10.1099/vir.0.054007-0. Epub 2013 Aug 1. PubMed PMID: 23907393.

41. Lu G, Guo W, Qi T, Ma J, Zhao S, Tian Z, Pan J, Zhu C, Wang X*, Xiang W*. Genetic analysis of the PB1-F2 gene of equine influenza virus. Virus Genes. 2013 Oct;47(2):250-8. doi: 0.1007/s11262-013-0935-x. Epub 2013 Jun 19. PubMed PMID:23780220.

42. Liu C, Guo W, Lu G, Xiang W, Wang X*. Complete genomic sequence of an equine herpesvirus type 8 Wh strain isolated from China. J Virol. 2012 May;86(9):5407. doi: 10.1128/JVI.00445-12. PubMed PMID: 22492929; PubMed Central PMCID: PMC3347380.

43. Wei L, Fan X, Lu X, Zhao L, Xiang W, Zhang X, Xue F, Shao Y, Shen R *, Wang X*, Genetic variation in the long terminal repeat associated with the transition of Chinese equine infectious anemia virus from virulence to avirulence. Virus Genes. 2009 Apr;38(2):285-8. doi: 10.1007/s11262-008-0317-y. Epub 2009 Jan 7. PubMed PMID: 19130201.

44. Abudu A, Wang X, Dang Y, Zhou T, Xiang SH, Zheng YH. Identification of molecular determinants from Moloney leukemia virus 10 homolog (MOV10) protein for virion packaging and anti-HIV-1 activity. J Biol Chem. 2012 Jan 6;287(2):1220-8. doi: 10.1074/jbc.M111.309831. Epub 2011 Nov 21. PubMed PMID: 22105071;

45.Wang X, Abudu A, Son S, Dang Y, Venta PJ, Zheng YH. Analysis of human APOBEC3H haplotypes and anti-human immunodeficiency virus type 1 activity. J Virol. 2011 Apr;85(7):3142-52. doi: 10.1128/JVI.02049-10. Epub 2011 Jan 26. PubMed PMID: 21270145; PubMed Central PMCID: PMC3067873.

46.Dang Y, Wang X, York IA, Zheng YH. Identification of a critical T(Q/D/E)x5ADx2(I/L) motif from primate lentivirus Vif proteins that regulate APOBEC3G and APOBEC3F neutralizing activity. J Virol. 2010 Sep;84(17):8561-70. doi: 10.1128/JVI.00960-10. Epub 2010 Jun 30. PubMed PMID: 20592083

47. Wang X, Han Y, Dang Y, Fu W, Zhou T, Ptak RG, Zheng YH. Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication. J Biol Chem. 2010 May 7;285(19):14346-55. doi: 10.1074/jbc.M110.109314. Epub 2010 Mar 9. PubMed PMID20215113; PubMed Central PMCID: PMC2863248.

48. Dang Y, Wang X, Zhou T, York IA, Zheng YH. Identification of a novel WxSLVK motif in the N terminus of human immunodeficiency virus and simian immunodeficiency virus Vif that is critical for APOBEC3G and APOBEC3F neutralization. J Virol. 2009 Sep;83(17):8544-52. doi: 10.1128/JVI.00651-09. Epub 2009 Jun 17. PubMed PMID: 19535447; PubMed Central PMCID: PMC2738151.

49. Zhou T, Han Y, Dang Y, Wang X, Zheng YH. A novel HIV-1 restriction factor that is biologically distinct from APOBEC3 cytidine deaminases in a human T cell line CEM.NKR. Retrovirology. 2009 Apr 3;6:31. doi: 10.1186/1742-4690-6-31. PubMed PMID: 19344514; PubMed Central PMCID: PMC2676246.

50. Han Y, Wang X, Dang Y, Zheng YH. Demonstration of a novel HIV-1 restriction phenotype from a human T cell line. PLoS One. 2008 Jul 30;3(7):e2796. doi:10.1371/journal.pone.0002796. PubMed PMID: 18665212; PubMed Central PMCID: PMC2464712.

51. Han Y, Wang X, Dang Y, Zheng YH. APOBEC3G and APOBEC3F require an endogenous cofactor to block HIV-1 replication. PLoS Pathog. 2008 Jul 4;4(7):e1000095. doi: 10.1371/journal.ppat.1000095. PubMed PMID: 18604271; PubMed Central PMCID: PMC2435275.

52. Dang Y, Siew LM, Wang X, Han Y, Lampen R, Zheng YH. Human cytidine deaminase APOBEC3H restricts HIV-1 replication. J Biol Chem. 2008 Apr 25;283(17):11606-14. doi: 10.1074/jbc.M707586200. Epub 2008 Feb 25. PubMed PMID: 18299330; PubMed Central PMCID: PMC2430661.

53. Wang X, Dolan PT, Dang Y, Zheng YH. Biochemical differentiation of APOBEC3F and APOBEC3G proteins associated with HIV-1 life cycle. J Biol Chem. 2007 Jan 19;282(3):1585-94. Epub 2006 Dec 1. PubMed PMID: 17142455; PubMed Central PMCID: PMC1880894.

54. Dang Y, Wang X, Esselman WJ, Zheng YH. Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family. J Virol. 2006 Nov;80(21):10522-33. Epub 2006 Aug 18. Erratum in: J Virol. 2011 May;85(10):5243. PubMed PMID: 16920826; PubMed Central PMCID: PMC1641744.

55. Zhou T, Yuan X, Hou S, Tu Y, Peng J, Wen J, Qiu H, Wu D, Chen HC, Wang X*, Tong GZ *. Long terminal repeat sequences from virulent and attenuated equine infectious anemia virus demonstrate distinct promoter activities. Virus Res. 2007 Sep; 128(1-2):58-64.

56. 戈曼,吴星亮,尹鑫,魏萍,王晓钧,SAMHD1蛋白的单克隆抗体制备及SAMHD1在不同细胞中的表达鉴定。中国预防兽医学报,2013,35(3):242-244.

57. 谷勤雍,胡哲,尹鑫,张泽力,吴星亮,魏萍,王晓钧*恒河猴Tetherin蛋白对马传染性贫血病毒抑制作用的研究,中国预防兽医学报2013352):87-90.

58.  王晓钧,魏丽丽,相文华,张晓燕,吕晓玲,赵立平,朱远茂,邵一鸣,沈荣显。中国马传染性贫血病毒驴强毒株感染性分子克隆的建立。中国农业科学, 2005, 38(9):1898-1904.

59.  王晓钧,魏丽丽,范秀娟,吕晓玲,相文华,张小燕,邵一鸣,沈荣显。马传染性贫血病毒疫苗致弱过程中不同代次毒株LTR序列变异。中国预防兽医学报, 2005, 27(3):179-183.

60.  王晓钧,贾斌,杨建德,田国斌,薛飞,唐秀英,相文华,沈荣显马流感病毒A/马/青海194株亚型鉴定及其HA基因序列特征。中国预防兽医学报2003, 25(3), 164-167.

61.  王晓钧相文华马流行性感冒。国外兽医学:畜禽传染病,199818(4)1-4

62. 刘益民左咏梅周艳君王晓钧*童光志*相文华沈荣显Tat蛋白对马传染性贫血病毒长末端重复序列启动子活性的影响中国兽医杂志2007, 37(4):301-304.(王晓钧为共同通讯作者)

63. 左咏梅吕晓玲赵立平李庆章郝艳红沈荣显相文华王晓钧*马传染性贫血病毒弱毒株LTR点突变型嵌合感染性克隆的构建名。中国预防兽医学报, 2007, 29(8):569-574 (王晓钧为通讯作者)

64. 魏丽丽,王晓钧**,耿庆华,童骁,粱华,沈韬,张小燕,相文华,邵一鸣,沈荣显。马传染性贫血病毒基因非编码区LTR嵌合克隆生物学特性的研究。病毒学报, 2006, 21(3):244-248. ( 王晓钧为通讯作者)

65. 耿庆华王晓钧相文华沈荣显马传染性贫血病毒阿根廷流行毒株前病毒gaggp90基因在马体内的变异分析畜牧兽医学报200637(3)270-273

66. 耿庆华王晓钧赵立平吕晓玲沈荣显相文华马传染性贫血病毒美洲流行株与我国弱毒疫苗株鉴别诊断方法的研究中国病毒学200621(1)81-83

67. 魏丽丽,王晓钧,王盈,粱华,沈韬,李景鹏,张小燕,相文华,邵一鸣,沈荣显。马传染性贫血病毒基因非编码区LTR嵌合克隆的构建。中国病毒学, 2005, 20(2):149-154.

68. 伏丽萍,王晓钧,魏丽丽,赵宇军,于敏,赵立平,吕晓玲,沈荣显,赵宏坤,相文华。猪群HEV血清抗体调查及一株新的猪HEV ORF2部分基因序列分析。中国预防兽医学报, 2005, 27(2):119-123.

69. 魏丽丽,王晓钧,王盈,李景鹏,相文华,沈荣显。马传染性贫血病毒自然感染马LTR序列分析。中国预防兽医学报, 2005, 27(2):81-84.

70.魏丽丽,王晓钧,王盈,李景鹏,相文华,沈荣显。马传染性贫血病毒Gag p9蛋白功能的研究进展。中国生物工程杂志, 2004, 24(12):10-13.

71. 魏丽丽,王晓钧,王盈,李景鹏,相文华,沈荣显。马传染性贫血病毒LTR的研究进展。中国预防兽医学报, 2004, 26(5):391-393.

72. 贾斌王晓钧,相文华,赵立平,吕晓玲,沈荣显。我国马流感病毒不同分离株实验感染SPF鸡的研究。中国预防兽医学报。199921(1)11-13.

73. 薛飞,朱远茂,王晓钧,杨建德,相文华,刘志英,赵立平,吕晓玲,沈荣显。马传染性贫血病毒驴白细胞弱毒疫苗株P15蛋白的克隆与表达。中国预防兽医学报2003, 25(1), 1-4.

74. 杨建德,薛飞,王晓钧,朱远茂,赵立平,吕晓玲,沈荣显,相文华,李景鹏。马流感病毒(A/Eq/Qinghai/1/94)NP基因的序列与同源性分析。中国预防兽医学报2003, 25(2), 96-98.

75. 马燕孟庆来段丹丽王晓钧刘颖相文华沈容显张晓燕邵一鸣痘苗病毒对马属动物细胞的感染性研究中国人兽共患病学报200723(2)149-152

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77. 薛飞朱远茂杨建德王晓钧相文华赵立平吕晓玲沈荣显马传贫驴白细胞弱毒疫苗株酸性蛋白p9基因的克隆与表达中国生物工程杂志200323(5)86-90

78. 杨建德王文军薛飞王晓钧朱远茂赵立平吕晓玲沈荣显许景军相文华马流感病毒(AEquineQinghai194)神经氨酸酶基因的克隆与同源性分析中国预防兽医学报200325(5)334-33

79. 王盈张晓燕魏丽丽吴东来王晓钧相文华沈荣显邵一鸣EIAV减毒疫苗免疫后马外周血单个核细胞中IFN-γ的转录。细胞与分子免疫学杂志, 2006, 22(4):436-439.

80. 朱远茂薛飞赵立平杨建德王晓钧吕晓玲相文华沈荣显马传染性贫血弱毒疫苗免疫马与自然感染马酶联免疫吸附试验血清抗体耐热性比较研究中国预防兽医学报,2005,27(1):46-49

81. 王盈张晓燕魏丽丽吴东来相文华王晓钧吕晓玲沈荣显邵一鸣EIAV减毒疫苗诱导马外周血单个核细胞Th1型细胞因子的转录。中国免疫学杂志, 2007, 23(8):709-713.

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83. 王盈,魏丽丽,张晓燕,吴东来,相文华,王晓钧,吕晓玲,沈荣显,邵一鸣。EIAV弱毒疫苗免疫马外周血单核细胞IL-2表达水平的研究。中国生物工程杂志, 2005, 25(5):55-59.

注:**为通讯作者

 

国际会议报告

 

1. Xiaojun Wang, William Fu, Travis Trgami, Megan Suer, Yanxing Han, Ying Dang, Tao Zhou, Roger Ptak, Yong-hui Zheng, Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication, Cold Spring Harbor Meeting on Retroviruses, 2010, May 24-29, Cold Spring Harbor, US

2. Xiaojun Wang, Wenhua Xiang, Xiaoyan Zhang, Bin Jia, Lili Wei, Xiujuan Fan, Xiaoling Lu, Yiming Shao, Rongxian Shen. Development and Characterization of a Pathogenic Molecular Clone of Chinese Equine Infectious Anemia Virus Donkey-adapted Strain. 5th Japan-China International Congress of Virology, 2004, June 10-11, Osaka University, Osaka, Japan.

 

国际会议文章

 

1. Xiaojun Wang, Ying Dang, Yong-hui Zheng, Human cytidine deaminase APOBEC3H restricts HIV-1 replication Cold Spring Harbor Meeting on Retroviruses, 2009, May 18-23, Cold Spring Harbor, US

2. Xiaojun Wang, Yanxing Han, Ying Dang,  Tao Zhou, Yong-hui Zheng, Characterization of the antiretroviral activivity of the RNA-induced silencing complex(RISC) Cold Spring Harbor Meeting on Retroviruses, 2008, May 19-24, Cold Spring Harbor, US

3. Xiaojun Wang, Ying Dang, Yong-hui,Zheng Fine mapping of the determinant that regulates APOBEC3 protein sensitivity to HIV-1 Vif-triggered degradation, Cold Spring Harbor Meeting on Retroviruses, 2007, May 20-25, Cold Spring Harbor, US.

4. Xiaojun Wang, Patrick T Dolan, Yong-hui Zheng, Biochemical differentiation of APOBEC3F and APOBEC3G proteins associated with HIV-1 life cycle. 13th West Coast Retrovirus Meeting, 2006, October 4-7, Palm Spring, US.

5. Ying Wang, Xiaoyan Zhang, Lili Wei, Donglai Wu, Wenhua Xiang, Xiaojun Wang, Rongxian Shen, Yiming Shao. Research on the distributing characterization of IFN-γ of EIAV attenuated vaccined horses. Congress of the Federation of Immunology Societies of Asia-Oceania Scientific Confirmation .2005.4 

 

 

 

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