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蔡雪辉

(2020-01-21 网页更新
1、个人简历
蔡雪辉,研究员,博士生导师,团队首席科学家。国务院特贴专家;国家“有突出贡献中青年科学家”;黑龙江省领军人才。主要集中于猪重要疫病的病原流行病学研究,侧重于PRRS、PRV的分子流行病学研究、病原学和分子致病机制的研究。作为第1、2发明人获得国家发明专利5项,获新兽药注册证书2个。以第一完成人获得国家科技进步2等奖1项、黑龙江省科技进步一等奖2项、神农中华农业科技奖一、二等奖各1项。发表SCI论文60余篇。
 
2、联系方式
(1)研究方向:动物病毒学及分子免疫学
(2)电话:0451-51051766
(3)邮箱:caixuehui@caas.cn 
(4)通讯地址:黑龙江省哈尔滨市香坊区哈平路678号,150069
 
3、教育经历 
2007.09-2012.12:吉林大学,动物医学院,获博士学位,预防兽医学;
1999.09-2003.01:东北农业大学,动物医学院,获硕士学位,预防兽医学;
1986.09-1990.07:东北农业大学,动物医学院,获学士学位,兽医公共卫生。
 
4、工作经历
2013.06-----现在:猪免疫抑制病研究创新团队首席科学家;
2014.09-2016.06:哈尔滨兽医研究所,动物疫病诊断中心主任;
2010.04-2014.09:哈尔滨兽医研究所,动物疫病诊断中心副主任;
2009.01-2013.06:哈尔滨兽医研究所猪病研究室研究组负责人,研究员;
2001.12-2009.01:哈尔滨兽医研究所猪病研究室研究组负责人,副研究员;
1996.12-2001.12:哈尔滨兽医研究所动物疫病防制室,助理研究员;
1993.05-1996.12:哈尔滨兽医研究所禽病研究室,研究实习员;
1990.07-1993.05:黑龙江省第一生物制品厂,见习兽医师。
 
5、承担项目
 “十二五”国家科技支撑计划:新型动物药剂创制与产业化关键技术研究,(2015BAD11B02,2015.04-2019.12),630万元.
 
6、代表论文与著作
   [1] Wang S, Gao M, An T, Liu Y, Jin J, Wang G, Jiang C, Tu Y, Hu S, Li J, Wang J, Zhou D*, Cai X*. Genetic diversity and virulence of novel sequence types of Streptococcus suis from diseased and healthy pigs in China. Front Microbiol. 2015;6:173.
   [2] Wang G, Yu Y, Tu Y, Tong J, Liu Y, Zhang C, Chang Y, Wang S, Jiang C, Zhou EM*, Cai X*. Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infection Induced Apoptosis and Autophagy in Thymi of Infected Piglets. PLoS One. 2015;10:e0128292.
   [3] Wang G, Yu Y, Tu Y, Li Y, Tong J, Zhang C, Liu Y, Li A, Jiang C, Wang S, Tao Y, Cai X*. Characterizing the thymic lesions in piglets infected with attenuated strains of highly pathogenic porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol. 2015. 168:258-61. 
   [4] Jiang C, An T, Wang S, Wang G, Si W, Tu Y, Liu Y, Wu J, Liu S*, Cai X*. Role of the ehxA gene from Escherichia coli serotype O82 in hemolysis, biofilm formation, and in vivo virulence. Can J Microbiol. 2015;61:335-41. 
   [5] Li Z, Wang G, Wang Y, Zhang C, Huang B, Li Q, Li L, Xue B, Ding P, Cai X*, Wang C*, Zhou EM*. Immune responses of pigs immunized with a recombinant porcine reproductive and respiratory syndrome virus expressing porcine GM-CSF. Vet Immunol Immunopathol. 2015;168:40-8. 
   [6] Yu Y, Wang G, Li Q, Du Y, Du T, Mu Y, Xiao S, Zhao Q, Wang C, Sun Y, Xu X, Zhang G, Hsu WH, Cai X*, Zhou EM*. Single-chain anti-idiotypic antibody retains its specificity to porcine reproductive and respiratory syndrome virus GP5. Immunol Lett. 2015;163:8-13.
   [7] Tu YB#*, Wang G#, Wang YQ, Chen WY, Zhang L, Liu YG, Jiang CG, Wang SJ, Bu ZG, Cai XH*. Extracellular expression and antiviral activity of a bovine interferon-alpha through codon optimization in Pichia pastoris. Microbiol Res. 2016, 191: 12-18. 
   [8] Wang G#, Yu Y#, Zhang C#, Tu YB, Tong J, Liu YG, Chang YF, Jiang CG, Wang SJ, Zhou E-M*, Cai XH*. Immune responses to modified live virus vaccines developed from classical or highly pathogenic PRRSV following challenge with a highly pathogenic PRRSV strain. Dev Comp Immunol. 2016, 62: 1-7. doi: 10.1016/j.dci.2016.04.019.
   [9] Dong JG#, Wang G#, Liu YG, Shi WD, Wu JN, Wen HQ, Wang SJ, Tian ZJ, Cai XH*. Quantitative estimation of the replication kinetics of genotype 2 PRRSV strains with different levels of virulence in vitro. J Virol Methods. 2016, 234: 87-9.
   [10] Wang G#, Li L#,Yu Y, Tu YB, Tong J, Zhang C, Liu YG, Li YM , Han ZF, Jiang CG, Wang SJ, Zhou E-M, He XJ*, Cai XH*. Highly pathogenic porcine reproductive and respiratory syndrome virus infection and induction of apoptosis in bone marrow cells of infected piglets. J Gen Virol. 2016, 97: 1356-1361.
   [11] Tang YD, Liu JT, Wang TY, An TQ, Sun MX, Wang SJ, Fang QQ, Hou LL, Tian ZJ, Cai XH. Live attenuated pseudorabies virus developed using the CRISPR/Cas9 system. Virus Res 2016, 225:33-39.
   [12] Tang YD#, Fang QQ#, Liu JT, Wang TY, Wang Y, Tao Y, Liu YG*, Cai XH*.  Open reading frames 1a and 1b of the porcine reproductive and respiratory syndrome virus (PRRSV) collaboratively initiate viral minus-strand RNA synthesis. Biochem Biophys Res Commun. 2016, doi: 10.1016/j.bbrc.2016. 06.161
   [13] Tang YD#, Liu JT#, Fang QQ#, Wang TY#, Sun MX, An TQ, Tian ZJ, Cai XH*. (2016b). Recombinant Pseudorabies Virus (PRV) Expressing Firefly Luciferase Effectively Screened for CRISPR/Cas9 Single Guide RNAs and Antiviral Compounds. Viruses. 2016, 8(4).
   [14] Mingxia Sun, Linlin Hou, Yan-dong Tang, Yonggang Liu, Shujie Wang, Jingfei Wang, Nan Shen, Tongqing An, Zhijun Tian & Xuehui Cai, Pseudorabies virus infection inhibits autophagy in permissive cells in vitro, Sci Rep. 2017 Jan 6;7:39964
   [15]Yan-Dong Tang, Ji-Ting Liu, Tong-Yun Wang, Ming-Xia Sun, Zhi-Jun Tian, Xue-Hui Cai* Comparison of Pathogenicity-Related Genes in the Current Pseudorabies Virus Outbreak in China. 2017, Sci Rep. 2017 Aug 10;7(1):7783. doi: 10.1038/s41598-017-08269-3.
   [16] Zhang HL, Zhang WL, Xiang LR, Leng CL, Tian ZJ, Tang YD, Cai XH. 2018. Emergence of novel porcine reproductive and respiratory syndrome viruses (ORF5 RFLP 1-7-4 viruses) in China. Vet Microbiol 222:105-108.
   [17] Zhang HL, Tang YD, Liu CX, Xiang LR, Zhang WL, Leng CL, Wang Q, An TQ, Peng JM, Tian ZJ, Cai XH. 2018. Adaptions of field PRRSVs in Marc-145 cells were determined by variations in the minor envelope proteins GP2a-GP3. Vet Microbiol 222:46-54.
   [18]Tang YD, Guo JC, Wang TY, Zhao K, Liu JT, Gao JC, Tian ZJ, An TQ, Cai XH. 2018. CRISPR/Cas9-mediated 2-sgRNA cleavage facilitates pseudorabies virus editing. FASEB J 32:4293-4301.
   [19] Wang HM, Liu TX, Wang TY, Wang G, Liu YG, Liu SG, Tang YD, Cai XH. 2018. Isobavachalcone inhibits post-entry stages of the porcine reproductive and respiratory syndrome virus life cycle. Arch Virol 163:1263-1270.
   [20]Wang TY, Liu YG, Li L, Wang G, Wang HM, Zhang HL, Zhao SF, Gao JC, An TQ, Tian ZJ, Tang YD, Cai XH. 2018. Porcine alveolar macrophage CD163 abundance is a pivotal switch for porcine reproductive and respiratory syndrome virus infection. Oncotarget 9:12174-12185.
   [21] Wang TY, Fang QQ, Cong F, Liu YG, Wang HM, Zhang HL, Tian ZJ, Tang YD, Cai XH. 2019. The Nsp12-coding region of type
   [22]PRRSV is required for viral subgenomic mRNA synthesis. Emerg Microbes Infect 8:1501-1510.
   [23]Wang TY, Yang YL, Feng C, Sun MX, Peng JM, Tian ZJ, Tang YD, Cai XH. 2020. Pseudorabies Virus UL24 Abrogates Tumor Necrosis Factor Alpha-Induced NF-kappaB Activation by Degrading P65. Viruses 12.
   [24]Wang SJ, Lyc C, Duan GX, Meng FD, Yang YB, Yu Y, He XJ, Wang ZZ, Gottschalk M, Li GW, Cai XH*, Wang G*.Streptococcus suis Serotype 2 Infection Causes Host Immunomodulation Through Induction of Thymic Atrophy. Infect Immun. 2020. Accept.
 
7、专利和标准
1)“猪繁殖与呼吸综合征病毒弱毒疫苗株及应用”。蔡雪辉,郭宝清,王洪峰,柴文君。发明专利,2009年,ZL 200710001253.0。
2)猪圆环病毒II型衣壳蛋白基因、表达载体的构建及其蛋白高效表达的方法。蔡雪辉,涂亚斌,武嘉男。发明专利,2013年,ZL201210128807.4。
3)猪链球SBP_bac_5基因缺失株及其构建方法和应用。蔡雪辉,王淑杰,刘永刚。发明专利,2017年,ZL201510058245.4。
4)实验动物麻醉用注射器。蔡雪辉,王淑杰。实用新型专利,2015年,ZL201420531444.3。
5)小动物手术用手术台。蔡雪辉,王淑杰。实用新型专利,2015年,ZL201520087430.1。
 
8、获得奖励
1)2006年和2009年获得省科学技术一等奖2项,排名第一;
2)2009年获神农中华农业科技奖二等奖1项,排名第一;
3)2010年获国家科技进步2等奖1项,排名第一;
4)2013年获“国务院特贴专家”称号;
5)2014年获“有突出贡献中青年科学家”称号;
6)2015年获“黑龙江省科技领军人才梯队带头人”称号;
7)2015年获“中华农业科技奖-优秀创新团队奖”排名第一;
8)2016年获“第二届哈尔滨科技创新团队奖”排名第一;
9)2017年获“黑龙江省劳动模范”称号。
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