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Asian black bear (Ursus thibetanus) picornavirus related to seal aquamavirus A. Arch Virol. 2018 Dec 20

Wang H , Zhang W , Yang S , Kong N , Yu H , Zheng H , Gao F , Tong W , Li L , Wang X , Deng X , Delwart E , Shan T .

 

Arch Virol. 2018 Dec 20. doi: 10.1007/s00705-018-4101-6. [Epub ahead of print]

 

Abstract

The complete genome of a bear picornavirus 1 (BePV-1) in the viscera of an Asian black bear (Ursus thibetanus) from China was characterized using viral metagenomics and RT-PCR/Sanger sequencing. The genome of BePV1 is 6703 nt long, contains a type-IV IRES 5'UTR with the '8-like' motif, encodes a 2053-aa-long polyprotein showing a 3-4-4 organization pattern and two 2A genes. BePV-1 showed the highest overall genome nucleotide sequence identity of 71.7% to a picornavirus genome from an Arctic ringed seal (Phoca hispida) from Canada, classified as a member of the species Aquamavirus A, currently the only one in the genus Aquamavirus. Phylogenetic and genetic distance analyses of P1 and 3D indicated that Asian bear picornavirus (aquamavirus B) represents the second sequenced member of the genus Aquamavirus.

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