Menghang Wang , Ying Yu, Jianan Wu , Fandan Meng, Yandong Tang, Shujie Wang, Yu Wang, Hongliang Cui, Xijun He, Yabin Tu, Gang Wang, Xuehui Cai 

Dis Markers.2021 Jun 24;2021:9434944.doi: 10.1155/2021/9434944. eCollection 2021.

Abstract

The clinical outcome of porcine circovirus 3 (PCV3) infection is still controversial. Herein, a novel PCV3 isolate (PCV3-China/DB-1/2017) with the molecular characterization of 24A and 27K in the Cap protein was used to inoculate three-week-old cesarean-derived, colostrum-deprived piglets. The nine PCV3 DB-1 inoculated piglets exhibited no obvious clinical symptoms or macroscopic lesions. PCV3 displayed a broad histotropism, including the heart, liver, spleen, lung, kidney, brain, lymph nodes, and tonsil, and the lungs and lymph nodes contained a higher quantity of viral genomes compared to that of the other organs. From 7 days after PCV3 DB-1 inoculation, the piglets showed obvious IgG antibody responses against PCV3 rCap-VLPs. The cumulative results demonstrated that PCV3 trend to low pathogenicity.

Copyright © 2021 Menghang Wang et al.