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Efficient inactivation of African swine fever virus by a highly complexed iodine.Vet Microbiol.2021 Sep 30;263:109245.doi: 10.1016/j.vetmic.2021.109245. Online ahead of print

Li Pan,Rui Luo,Tao Wang,Mengnan Qi,Bing Wang,Maowen Sun,Yuzi Luo,Chen Ji,Yuan Sun,Hua-Ji Qiu

 

Vet Microbiol.2021 Sep 30;263:109245.doi: 10.1016/j.vetmic.2021.109245. Online ahead of print.

 

Abstract

African swine fever (ASF) is a highly lethal contagious disease of swine caused by African swine fever virus (ASFV). Cleaning and disinfection remain one of the most effective tools to prevent the ASFV spread in pig holdings. This study evaluated the inactivation effect of a highly complexed iodine (HPCI) disinfectant against ASFV. A commercially available povidone-iodine (PVP-I) was used as reference for comparison. The results showed that 5% HPCI and 5% PVP-I did not exhibit cytotoxicity in primary porcine alveolar macrophages, and 107.0 and 105.0 TCID50/mL ASFV were completely inactivated by 5% and 0.25% HPCI, respectively, in 5 min via either immersion or spray disinfection. However, 5% PVP-I required at least 15 min to completely inactivate 107.0 TCID50/mL ASFV, whereas 0.25% PVP-I failed to completely inactivate 105.0 TCID50/mL ASFV. This study demonstrated that HPCI could rapidly and efficiently inactivate ASFV, representing an effective disinfectant for ASF control.

Keywords: African swine fever virus; Disinfectant; Highly complexed iodine; Inactivation.

Copyright © 2021 Elsevier B.V. All rights reserved.

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