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Phylogenitc analysis and immunogenicity comparision of porcine genotype G9 rotavirus in China from 2020-2023.Virol Sin.2025 Feb 21:S1995-820X(25)00007-0.doi: 10.1016/j.virs.2025.02.003

Yudi Pan , Zixin Li , Qian Miao , Hongyan Shi , Longjun Guo , Li Feng , Jin Tian 

Virol Sin.2025 Feb 21:S1995-820X(25)00007-0.doi: 10.1016/j.virs.2025.02.003. Online ahead of print.

Abstract

As an emerging genotype, the G9 genotype rotaviruses (RVs) are widespread among humans and pigs, and have been reported in many countries and regions in the recent years. Moreover, porcine G9 strains could cross the interspecies barrier to infect human. To investigate the epidemic trends of porcine G9 strains as well as the cross-immunoreactivity among different isolates, an epidemiological investigation about porcine G9 genotype RVs (PoRVs) was performed during the period 2020-2023 in multiple provinces of China. A total of nine representative strains were identified. The phylogenetic analysis based on viral VP7 gene showed that these strains mainly clustered with lineages III and VI, which revealed the predominant G9 PoRVs in China. Moreover, a new lineage, lineage VII, was identified, and strains of this lineage were found to be circulating in Guangdong and Taiwan. Except lineages I and IV, some isolates from other lineages could co-circulate in pigs and humans. Three G9 strains, namely 923H, 923E, and 923X, which belonged to the largest sub-lineage III, were isolated. Then, the significant cross-reactivity was observed among strains of the same or different lineages. This study is the first to systematically investigate the genetic and immunogenetic characteristics of porcine G9 genotype rotavirus in China, as well as the potential cross-species transmission between pigs and humans, providing a valuable direction for the effective prevention of porcine rotavirus.

Keywords: G9; Genetic and immunogenetic characterization; Pig; Rotavirus (RV).


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