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团队成员

黄 丽

1、个人简历

    黄丽,女,博士,副研究员,硕士生导师,基础免疫创新团队。长期从事猪脑心肌炎病毒(EMCV)与宿主相互作用研究以及病毒逃逸宿主天然免疫机制研究。主持国家自然科学基金一项。在Journal of Biological Chemistry等专业杂志发表科技论文21篇。其中第一作者6篇,共同通讯作者1篇。获得国家发明专利1项。获得中华农业科技奖一项。

 

2、联系方式

1)研究方向:兽医微生物及其分子生物学

2)电话:0451-51051759

3)邮箱:highlight0315@163.com

4)通讯地址:黑龙江省哈尔滨市香坊区哈平路678

 

3、教育经历

2007/09–2012/06,南京农业大学,预防兽医学专业,博士。

 

4、工作经历

2012/07-2016/12,中国农业科学院哈尔滨兽医研究所,助理研究员。

2017/01-至今,中国农业科学院哈尔滨兽医研究所,基础免疫创新团队,副研究员。

 

5、承担项目

(1)  国家自然科学基金青年基金:20S蛋白酶体亚基在脑心肌炎病毒复制与组装中的作用,(31300139,2014.01-2016.12),23万;

(2)  兽医生物技术国家重点实验室基本科研业务费:EMCV 3C蛋白酶切割TANK的功能研究,(SKLVBP201432,2014.01-2014.12),10万元。

 

6、代表论文与著作

 (1)  Li Huang, Tao Xiong, Huibin Yu, Quan Zhang, Kunli Zhang, Changyao Li, Liang Hu, Yuanfeng Zhang, Lijie Zhang, Qinfang Liu, Shengnan Wang, Xijun He, Zhigao Bu, Xuehui Cai, Shangjin Cui, Jiangnan Li and Changjiang Weng*. Encephalomyocarditis virus 3C protease attenuates type I interferon production through disrupting the TANK–TBK1–IKKε–IRF3 complex. Biochemical Journal. 2017 474: 2051-2065.

 (2)  Huibin Yu1, Li Huang1, Yuanfeng Zhang, Liang Hu, Shengnan Wang, Jiangnan Li, Xuehui Cai, Shangjin Cui, Changjiang Weng. An attenuated EMCV-HB10 strain acts as a live viral vector delivering a foreign gene. J Gen Virol. 2016 Sep;97(9):2280-90.

 (3)  Li Huang, Qinfang Liu, Lijie Zhang, Quan Zhang, Liang Hu, Changyao Li, Shengnan Wang, Jiangnan Li, Yuanfeng Zhang, Huibin Yu, Yan Wang, Zhaohua Zhong, Tao Xiong, Xueshan Xia, Xiaojun Wang, Li Yu, Guohua Deng, Xuehui Cai, Shangjin Cui, Changjiang Weng*. Encephalomyocarditis Virus 3C Protease relieves TANK Inhibitory Effect on TRAF6-mediated NF-kappaB Signaling through Cleavage of TANK, J Biological Chemistry, 2015, 290(46): 27618-32.

 (4)  Li Huang, Ruibing Cao, Ning Wang, Ke Liu, Jianchao Wei, Hassan Isahga, Lijie Song Weiyong Zuo, Bin Zhou, Weiwu Wang, Xiang Mao*, Puyan Chen*. The design and Recombinant Protein expression of a Consensus Porcine Interferon: CoPoIFN-α, Cytokine, 2012, 57(1): 37-45.

 (5)  Li Huang, Xiang Mao*, Najmoutin G. Abdulaev, Tony Ngo, Wei Liu, and Kevin D. Ridge. One-step Purification of a Functional, Constitutively Activated Form of Visual Arrestin, Protein expression and purification, 2012, 82(1): 55-60.

 (6)  Li Huang, Yuanpeng Zhang, Yaling Yu, Mingxia Sun, Chen Li, Bo Ni, Xiuhua Wang, Puyan Chen, Xiang Mao*. Role of cholesterol in porcine reproductive and respiratory syndrome virus (PRRSV) infection on MARC-145 cells. Biochemical and Biophysical Research Communications. 2011, 414(3): 545-50.

 (7)  Jiangnan Li, Shengnan Wang, Li Huang*, Changjiang Weng*. Secondary Haemophilus parasuis infection enhances highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection-mediated inflammatory responses. Vet Microbiol. 2017, 204: 35-42.

 (8)  Jiangnan Li, Liang Hu, Yuanyuan Liu, Li Huang, Yang Mu, Xuehui Cai, Changjiang Weng*, DDX19A Senses Viral RNA and Mediates NLRP3-Dependent Inflammasome Activation, Journal of Immunology 2015.12.15, 19512: 5732-5749

 (9)  Jiangnan Li, Dongwei, Guo, Li Huang, Manman Yin, Qingfang Liu, Yan Wang, Chunmei Yang, Yuanyuan Liu, Lijie Zhang, Zhijun Tian, Xuehui Cai, Liyun Yu, Changjiang Weng*, The interaction between host Annexin A2 and viral Nsp9 is beneficial for replication of porcine reproductive and respiratory syndrome virus, Virus Research, 2014, 30(189): 106-113.

 (10)  Ming-xia Sun, Li Huang, Rui Wang, Ya-ling Yu, Chen Li, Peng-peng Li, Xiao-chun Hu, Hong-ping Hao, Hassan. A. shag, Xiang Mao. Porcine Reproductive and Respiratory syndrome Virus Induce Autophagy to Promote Virus Replication. Autophagy. 2012, 8:1434-1447.

 

7、专利和标准

黄丽,陈溥言,刘珂,茅翔,魏建超,一种复合猪α干扰素基因及其重组载体,ZL201010125057.6

 

(2019年6月更新)

 

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