1、个人简历

张洪亮，博士，副研究员。主要从事猪蓝耳病及猪病新发病原的流行病学和防控技术研究，2015年首次分离和报道2.1d新亚型猪瘟病毒，评价了C株对2.1d新亚型猪瘟病毒的保护效果。2016年完成了类NADC30 PRRSV的致病性及当前疫苗的保护效果，研制了针对类NADC30 PRRSV的疫苗候选株。2018年首次分离和报道我国出现类NADC34（1-7-4分支）猪蓝耳病病毒，并评价了类NADC34 PRRSV的致病性及在我国的流行情况。参与类NADC30猪繁殖与呼吸综合征活疫苗（SD-R株）创制和猪伪狂犬病活疫苗（TP株）创制。主持国家自然基金1项，博士后基金1项，黑龙江省自然基金1项。以第一作者（含共第一）和通讯作者（含共通讯）发表论文43篇，其中SCI论文27篇，中文核心论文16篇。

2、联系方式

研究方向：动物疫苗与分子免疫学

电话：13624503578

邮箱：zhanghongliang01@caas.cn

通讯地址：哈尔滨市香坊区哈平路678号 

3、教育经历

2009.09～2013.06  青岛农业大学动物医学专业 学士

2013.09～2016.06  中国农业科学院预防兽医学专业 硕士

2016.09～2019.06  中国农业科学院预防兽医学专业 博士

2019.07～2023.04  中国农业科学院 博士后

4、工作经历

2023.05～   中国农业科学院哈尔滨兽医研究所 副研究员

5、承担项目

1. 国家自然基金青年科学基金项目：I型和II型猪繁殖与呼吸综合征病毒抗体鉴别诊断靶点筛选及鉴定（32002315），24万元。

2. 第68批博士后基金：猪繁殖与呼吸综合征活疫苗交叉保护的分子机制（2020M680788），8万元。

3. 黑龙江省自然科学基金优秀青年项目：猪繁殖与呼吸综合征病毒活疫苗诱导猪体抗体应答差异的分子机制（YQ2022C042），10万元。

4. 国家生猪技术创新中心牧原项目：欧洲型PRRSV抗原抗体鉴别诊断方法建立（NCTIP-MY23001），30万元。

6、代表论文

1. Zhang H, Feng L, Liu C, Chen J, Leng C, Bai Y, Peng J, An T, Cai X, Yang X, Tian Z, Tong G. Complete Genome Sequence of Classical Swine Fever Virus Strain JSZL, Belonging to a New Subgenotype, 2.1d, Isolated in China in 2014. Genome Announc. 2015 Aug 20;3(4):e00833-15. (First author)

2. Zhang H., Leng, C., Feng, L., Zhai, H., Chen, J., Liu, C., Bai, Y., Ye, C., Peng, J., An, T., Kan, Y., Cai, X., Tian, Z., Tong, G., 2015. A new subgenotype 2.1d isolates of classical swine fever virus in China, 2014. Infect Genet Evol 34, 94-105. (First author)

3. Zhang, H.L., Zhang, W.L., Xiang, L.R., Leng, C.L., Tian, Z.J., Tang, Y.D., Cai, X.H., 2018. Emergence of novel porcine reproductive and respiratory syndrome viruses (ORF5 RFLP 1-7-4 viruses) in China. Vet Microbiol 222, 105-108. (First author)

4. Zhang H, Leng C, Ding Y, Zhai H, Li Z, Xiang L, Zhang W, Liu C, Li M, Chen J, Bai Y, Kan Y, Yao L, Peng J, Wang Q, Tang YD, An T, Cai X, Tian Z, Tong G. Characterization of newly emerged NADC30-like strains of porcine reproductive and respiratory syndrome virus in China. Arch Virol. 2019 Feb;164(2):401-411. (First author)

5. Zhang WL, Zhang HL, Xu H, Tang YD, Leng CL, Peng JM, Wang Q, An TQ, Cai XH, Fan JH, Tian ZJ. Two novel recombinant porcine reproductive and respiratory syndrome viruses belong to sublineage 3.5 originating from sublineage 3.2. Transbound Emerg Dis. 2019 Nov;66(6):2592-2600. (Co-first author)

6. Xu H, Song S, Zhao J, Leng C, Fu J, Li C, Tang YD, Xiang L, Peng J, Wang Q, Zhao H, An T, Cai X, Zhang H, Tian ZJ. A potential endemic strain in China: NADC34-like porcine reproductive and respiratory syndrome virus. Transbound Emerg Dis. 2020 Jul;67(4):1730-1738. (Co-corresponding author)

7. Song S, Xu H, Zhao J, Leng C, Xiang L, Li C, Fu J, Tang YD, Peng J, Wang Q, Zhao H, An T, Cai X, Zhang H, Tian ZJ. Pathogenicity of NADC34-like PRRSV HLJDZD32-1901 isolated in China. Vet Microbiol. 2020 Jul;246:108727. (Co-corresponding author)

8. Zhang HL, Li YM, Sun J, Zhang YY, Wang TY, Sun MX, Wang MH, Yang YL, Hu XL, Tang YD, Zhao J, Cai X. Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species. J Biol Chem. 2021 Jan-Jun;296:100435. (First author)

9. Li C, Gong B, Sun Q, Xu H, Zhao J, Xiang L, Tang YD, Leng C, Li W, Guo Z, Fu J, Peng J, Wang Q, Zhou G, Yu Y, Meng F, An T, Cai X, Tian ZJ, Zhang H. First Detection of NADC34-like PRRSV as a Main Epidemic Strain on a Large Farm in China. Pathogens. 2021 Dec 29;11(1):32. (Corresponding author)

10. Xu H, Li C, Li W, Zhao J, Gong B, Sun Q, Tang YD, Xiang L, Leng C, Peng J, Wang Q, Meng F, Yu Y, An T, Cai X, Tian ZJ, Zhang H. Novel characteristics of Chinese NADC34-like PRRSV during 2020-2021. Transbound Emerg Dis. 2022 Sep;69(5):e3215-e3224. (Corresponding author)

11. Xu H, Xiang L, Tang YD, Li C, Zhao J, Gong B, Sun Q, Leng C, Peng J, Wang Q, Zhou G, An T, Cai X, Tian ZJ, Zhang H, Song M. Genome-Wide Characterization of QYYZ-Like PRRSV During 2018-2021. Front Vet Sci. 2022 Jun 30;9:945381. (Co-corresponding author)

12. Xiang L, Xu H, Li C, Tang YD, An TQ, Li Z, Liu C, Song S, Zhao J, Leng C, Qu X, Sun Y, Peng J, Wang Q, Cai X, Tian ZJ, Zhang H. Long-Term Genome Monitoring Retraces the Evolution of Novel Emerging Porcine Reproductive and Respiratory Syndrome Viruses. Front Microbiol. 2022 Apr 13;13:885015. (Corresponding author)

13. Sun Q, Xu H, Li C, Gong B, Li Z, Tian ZJ, Zhang H. Emergence of a novel PRRSV-1 strain in mainland China: A recombinant strain derived from the two commercial modified live viruses Amervac and DV. Front Vet Sci. 2022 Sep 9;9:974743. (Corresponding author)

14. Zhang H, Xiang L, Xu H, Li C, Tang YD, Gong B, Zhang W, Zhao J, Song S, Peng J, Wang Q, An T, Cai X, Tian ZJ. Lineage 1 Porcine Reproductive and Respiratory Syndrome Virus Attenuated Live Vaccine Provides Broad Cross-Protection against Homologous and Heterologous NADC30-Like Virus Challenge in Piglets. Vaccines (Basel). 2022 May 10;10(5):752. (First author)

15. Li C, Xu H, Zhao J, Gong B, Sun Q, Xiang L, Li W, Guo Z, Li J, Tang YD, Leng C, Peng J, Wang Q, An T, Cai X, Tian ZJ, Zhou G, Zhang H. Epidemiological investigation and genetic evolutionary analysis of PRRSV-1 on a pig farm in China. Front Microbiol. 2022 Dec 1;13:1067173. (Corresponding author)

16. Guo Z, Zhang S, Xu H, Li W, Li C, Zhao J, Gong B, Sun Q, Xiang L, Zhao H, Wang Q, Zhou G, Tang Y, An T, Cai X, Tian Z, Zhang H, Peng J. Preparation and Identification of a Monoclonal Antibody against the Pseudorabies Virus gE Glycoprotein through a Novel Strategy. Vet Sci. 2023 Feb 9;10(2):133. (Co-corresponding author)

17. Xu H, Gong B, Sun Q, Li C, Zhao J, Xiang L, Li W, Guo Z, Tang Y, Leng C, Li Z, Wang Q, Zhou G, An T, Cai X, Tian Z, Peng J, Zhang H. Genomic Characterization and Pathogenicity of BJEU06-1-Like PRRSV-1 ZD-1 Isolated in China, Transbound Emerg Dis, vol. 2023, Article ID 6793604, 12 pages, 2023. (Corresponding author)

18. Li W, Li C, Guo Z, Xu H, Gong B, Sun Q, Zhao J, Xiang L, Leng C, Peng J, Zhou G, Tang Y, Liu H, An T, Cai XH, Tian ZJ, Wang Q, Zhang H. Genomic characteristics of a novel emerging PRRSV branch in sublineage 8.7 in China. Front Microbiol. 2023 May 31;14:1186322. (Corresponding author)

19. Sun Q, Xu H, An T, Cai X, Tian Z, Zhang H. Recent Progress in Studies of Porcine Reproductive and Respiratory Syndrome Virus 1 in China. Viruses. 2023 Jul 10;15(7):1528. (Corresponding author)

20. Xu H, Li C, Gong B, Li W, Guo Z, Sun Q, Zhao J, Xiang L, Li J, Tang YD, Leng C, Wang Q, Peng J, Zhou G, Liu H, An T, Cai X, Tian ZJ, Zhang H. Protective Efficacy of a Candidate Live-Attenuated Vaccine Derived from the SD-R Strain against NADC34-like Porcine Reproductive and Respiratory Syndrome Virus. Vaccines (Basel). 2023 Aug 9;11(8):1349. (Corresponding author)

21. Zhang H, Li C, Xu H, Gong B, Li W, Guo Z, Xiang L, Sun Q, Zhao J, Peng J, Wang Q, Zhou G, Tang Y-D, An T, Cai X-H, Tian Z-J. Protective efficacy of a candidate live attenuated vaccine derived from the SD-R strain of lineage 1 porcine reproductive and respiratory syndrome virus against a lethal challenge with HP-PRRSV HuN4 in piglets. Microbiol Spectr. 2023 Dec 12;11(6):e0198423. (First author)

22. Li C, Zhao J, Li W, Xu H, Gong B, Sun Q, Guo Z, Li J, Xiang L, Tang YD, Leng C, Wang Q, Peng J, Zhou G, Liu H, An T, Cai X, Tian ZJ, Zhang H. Prevalence and genetic evolution of porcine reproductive and respiratory syndrome virus in commercial fattening pig farms in China. Porcine Health Manag. 2024 Jan 22;10(1):5. (Corresponding author)

23. Guo Z, Xu H, Zhang S, Kang H, Li C, Sun Q, Zhao J, Li J, Zhou G, Wang Q, Xiang L, Tang Y, Liu H, Leng C, An T, Cai X, Tian Z, Zhang H, Peng J. Improved detection sensitivity of anti-PRV variant antibodies through preparation of anti-gB and anti-gE monoclonal antibodies and development of blocking ELISAs. Int J Biol Macromol. 2024 Mar;260(Pt 1):129425. (Co-corresponding author)

24. Gong B, Xu H, Sun Q, Li C, Xiang L, Zhao J, Li W, Guo Z, Li J, Wang Q, Peng J, Zhou G, Leng C, Tang YD, Wu J, Liu H, An TQ, Cai X, Tian ZJ, Zhang H, Dissecting Genetic Diversity and Evolutionary Trends of Chinese PRRSV-1 Based on Whole-Genome Analysis, Transboundary and Emerging Diseases, 2024, 9705539, 15 pages, 2024. (Corresponding author)

25. Li J, Xu H, Li C, Zhao J, Gong B, Sun Q, Guo Z, Zhang S, Zhang M, Xiang L, Tang Y, Wu J, Wang Q, Peng J, Zhou G, Liu H, An T, Cai X, Tian ZJ, Zhang H, Genomic Characterization of HLJDZD55: The First L1B PRRSV in China, Transboundary and Emerging Diseases, 2024, 2969771, 8 pages, 2024. (Corresponding author)

26. Xu H, Zhang S, Guo Z, Li C, Gong B, Li J, Sun Q, Zhao J, Zhang M, Xiang L, Tang Y, Leng C, Wu J, Wang Q, Peng J, Zhou G, Liu H, An T, Cai X, Tian Z, Zhang H. Novel characterization of NADC30-like and NADC34-like PRRSV strains in China: epidemiological status and pathogenicity analysis of L1A variants, Journal of Integrative Agriculture, https://doi.org/10.1016/j.jia.2024.03.056(Corresponding author)

27. Li C, Li J, Gong B, Xu H, Guo Z, Xiang L, Zhang S, Sun Q, Zhao J, Zhang M, Tang YD, Leng C, Wu J, Wang Q, Peng J, Zhou G, Liu H, An T, Cai X, Tian ZJ, Zhang H. A lineage 1 branch porcine reproductive and respiratory syndrome virus live vaccine candidate provides broad cross-protection against HP-like PRRSV in piglets. Virulence. 2025 Dec;16(1):2451754. (Corresponding author)

7、专利和标准

1. 发明人：田志军，张洪亮，蔡雪辉，相丽润，王倩，汤艳东，彭金美，安同庆 专利名称：类NADC30猪蓝耳病强毒株、弱毒株及其应用。专利号：202010580477.7

2. 发明人：田志军，张洪亮，许浒，相丽润，彭金美，王倩，周国辉，蔡雪辉，汤艳东，安同庆 专利名称：分泌欧洲型PRRSV特异性单克隆抗体的杂交瘤细胞系EU1及其竞争ELISA方法的建立。专利号：202110995235.9

3. 发明人：张洪亮，田志军，王倩，彭金美，周国辉 专利名称：一种分泌高致病性猪繁殖与呼吸综合征病毒特异性单克隆抗体的杂交瘤细胞株及其应用。专利号：202311001871.0

4. 发明人：彭金美，田志军，张洪亮，王倩，周国辉 专利名称：一种分泌抗猪伪狂犬病病毒gB蛋白抗体的单克隆杂交瘤细胞株及其应用。专利号：202310770698.4

8、获得奖励

1. 获评为中国农业科学院2020年度第二批优秀博士后。

2. 获得第十三届中国创新创业大赛创新挑战赛（重庆）生猪技术专业赛金奖。

3. 获得黑龙江省首届环大学大院大所创新创业生态圈科技成果擂台赛三等奖。