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团队成员

周国辉

1、个人简历

     周国辉,男,1977.6出生,新疆阿勒泰人,副研究员。1999年获新疆农业大学学士学位,2005年获新疆农业大学硕士学位,2011年获东北农业大学博士学位。2005 年进入哈尔滨兽医研究所牛羊传染病研究创新团队参加工作。先后主持和参加国家自然科学基金,中央级公益性科研院所基本科研业务费专项,兽医生物技术国家重点实验室自主研究课题,863子课题,“十一”五黑龙江省科技攻关重大项目等项目研究。现主要从事口蹄疫抗体诊断和监测技术的研究。
 
2、联系方式
(1)研究方向:兽医微生物及其分子生物学
(2)电话:13946086907
(3)邮箱:ghzhoubt@163.com
(4)通讯地址:黑龙江省哈尔滨市香坊区哈平路678号
 
3、教育经历 
1995.09-1999.06  新疆农业大学,动物科技学院,学士
2002.09-2005.06  新疆农业大学,预防兽医专业,硕士
2008.09-2011.06  东北农业大学,预防兽医专业,博士
2005年至今  中国农业科学院哈尔滨兽医研究所工作
 
4、工作经历
2005.07-今       中国农科院哈尔滨兽医研究所, 副研究员
 
5、承担项目

   1.  亚洲1 型FMD病毒样颗粒展示O型FMDV优势中和表位的研究(项目编号:31101801)  国家自然科学基金  21万元  2012-2014  主持

 

6、代表论文与著作

   1. Mingxia Wang, Zhiqiang Xu, Wenming Liu, Minjie Li, Haiwei Wang, Decheng Yang, Wenge Ma, Guohui Zhou*, Li Yu.Identification of a conserved linear epitope using monoclonal antibody against non-structural protein 3A of foot-and-mouth disease virus with potential for differentiation between infected and vaccinated animals。Res Vet Sci, 124:178–185.

   2. Wenming Liu, Baolin Yang, Mingxia Wang, Weifeng Liang, Haiwei Wang, Decheng Yang, Wenge Ma, Guohui Zhou*, Li Yu * (2017) Identification of a conserved conformational epitope in the VP2 protein of foot-and-mouth disease virus. Arch Virol, 162:1877–1885.

   3. Wenming Liu†, Baolin Yang†, Mingxia Wang, Haiwei Wang, Decheng Yang, Wenge Ma, Guohui Zhou*, Li Yu (2017) Identification of a conformational neutralizing epitope on the VP1 G-H loop of type A foot-and-mouth disease virus. (2017) Res Vet Sci, 115, 374–381.

   4. Baolin Yang, Mingxia Wang, Wenming Liu, Zhiqiang Xu, Haiwei Wang, Decheng Yang, Wenge Ma, Guohui Zhou*, Li Yu.  Identification of a serotype-independent linear epitope of foot-and-mouth disease virus. (2017).Arch Virol.2017 162, 3875–3880.

   5. Weifeng Liang, Guohui Zhou, Wenming Liu1,Baolin Yang, Chaosi Li, Haiwei Wang, Decheng Yang, Wenge Ma, Li Yu 1  Identification of a conserved linear neutralizing epitope recognized by monoclonal antibody . Arch Virol (2016) 161:2705–2716

   6. Chaosi Li, Weifeng Liang, Wenming Liu, Decheng Yang, Haiwei Wang, Wenge Ma, Guohui Zhou*, Li Yu. Identification of a conserved linear epitope using a monoclonal antibody against non-structural protein 3B of foot-and-mouth disease virus Arch Virol (2016) 161:365–375

   7. Zhou G, Wang H, Wang F, Yu L. Recombinant Adenovirus Expressing Type Asia1 Foot-and-mouth Disease Virus Capsid Proteins Induces Protective Immunity against Homologous Virus Challenge in Mice. Res Vet Sci. 2013 Jun;94(3):796-802.

   8. Chai Z, Wang H, Zhou G, Yang D, Wang J, Yu L. Adenovirus-vectored type Asia1 foot-and-mouth disease virus (FMDV) capsid proteins as a vehicle to display a conserved, neutralising epitope of type O FMDV. Journal of Virological Methods. 2013,188(1-2):175-82.

   9. Xue M, Wang H, Li W, Zhou G, Tu Y, Yu L.Effects of amino acid substitutions in the VP2 B-C loop on antigenicity and pathogenicity of serotype Asia1 foot-and-mouth disease virus. Virol J. 2012,10;9(1):191.

   10. Haiwei Wang, Mei Xue, Decheng Yang, Guohui Zhou, Donglai Wu and Li Yu .Insertion of type O-conserved neutralizing epitope into the foot-and-mouth disease virus type Asia1 VP1 G-H loop: effect on viral replication and neutralization phenotype. J Gen Virol. 2012,93:1442-8.

   11. Yang D, Zhang C, Zhao L, Zhou G, Wang H, Yu Li.Identification of a conserved linear epitope on the VP1 protein of serotype O Foot-and-Mouth Disease Virus by neutralising monoclonal antibody 8E8. Virus Research. 2011,155(1),291-299.

   12. Haiwei Wang, Lei Zhao,Wan Li,Guohui Zhou,,Li Yu.Identification of a Conformational Epitope on the VP1 G-H Loop of Type Asia1 Foot-and-Mouth Disease Virus Defined by a Protective Monoclonal Antibody. Vet Microbiol. 2011, 148(2-4):189-199

   13. Jianxiong Zeng*, Haiwei Wang*, Xiaochun Xie, Chen Li, Guohui Zhou, Decheng Yang, Li Yu*. Ribavirin-resistant variants of foot-and-mouth disease virus: the effect of restricted quasispecies diversity on viral virulence. Journal of virology. 2014(88).
 
7、专利和标准

   1.周国辉. 表达亚洲1型口蹄疫病毒VLP的重组腺病毒及其应用,2010,中国,国家发明专利授权号:ZL201010114532.X

   2.周国辉. 抗口蹄疫病毒的单克隆抗体及其识别的表位和应用,2010,中国,国家发明专利授权号:ZL200810171257.8

   3.周国辉. O型口蹄疫病毒变异株及其编码基因和应用,2010,中国,国家发明专利授权号:ZL201010160669.9

   4.周国辉. 表达O型口蹄疫病毒空衣壳的重组缺损腺病毒及其应用,2014,中国,国家发明专利号ZL 201210030115.6

   5.周国辉. 表达O型口蹄疫病毒空衣壳的重组缺损腺病毒及其应用,2017,中国,国家发明专利号ZL 201410030113.2

   6.周国辉. A型口蹄疫病毒单克隆抗体识别的中和表位及其应用,2019,中国,国家发明专利号ZL 2016101183394.8

   7.周国辉.抗A型口蹄疫病毒中和性单克隆抗体及其应用,2019,中国,国家发明专利号ZL 201610183404.8

   8.周国辉. 分泌口蹄疫病毒共享型单克隆抗体10B10的杂交瘤细胞系及其应用,2019,中国,国家发明专利号ZL 201710349810.1

 

8、转基因安全证书

    表达O型口蹄疫病毒外壳蛋白的重组腺病毒rAdV-O-P12A3C疫苗生产应用的安全证书。 农基安证字(2018)第047号

 
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