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团队成员

李 刚

1、个人简历

李刚,男,副研究员,硕士研究生导师,动物细菌病创新团队骨干成员,主要从事猪呼吸道细菌病致病机制及新型疫苗研究,先后主持和参与国家自然科学基金等10余项。在 Journal of Bacteriology、Journal of Proteomics 等国内外重要学术刊物发表论文20多篇,获得省市级奖励2项,获得国家发明专利10余项。

2、联系方式

(1)研究方向:兽医微生物及其分子生物学

(2)电话:0451-51051735

(3)邮箱:ligang@caas.cn

(4)通讯地址:黑龙江省哈尔滨市香坊区哈平路678号

3、教育经历

1998.09-2002.07  东北农业大学  植物保护  学士

2002.09-2005.07  东北农业大学  植物病理  硕士

2005.09-2010.04  中国科学院微生物研究所  微生物学  博士

4、工作经历

2010.07-2011.01  中国农业科学院哈尔滨兽医研究所   研究实习员

2011.01-2018.12  中国农业科学院哈尔滨兽医研究所   助理研究员

2018.05-2019.05  中国生物技术发展中心战略与政策处   借调

2019.01-至今  中国农业科学院哈尔滨兽医研究所   副研究员

5、承担项目

1) 国家自然科学基金面上项目:猪链球菌的eSTK/eSTP系统对反应调节因子CovR的调控及其机制研究(31772757,2018.01 -2021.12),62万,参与;

2) 黑龙江省自然科学基金面上项目:胸膜肺炎放线杆菌持留菌形成的分子机制研究(C2017078,2017.01-2020.12),6万元,主持;

3) 国家自然科学基金面上项目:(p)ppGpp诱导胸膜肺炎放线杆菌形成持留菌的分子机制研究(31672575,2017.01-2020.12),62万元,主持;

4) 国家自然科学基金青年项目:SK2b型A族链球菌激活纤溶酶原的分子机制的研究(31500112,2016.01-2018.12),19万,参与;

5) 国家自然科学基金青年项目:氨基酸饥饿状态下(p)ppGpp调控胸膜肺炎放线杆菌致病性研究(31302091,2014.01-2016.12),25万元,主持;

6) 中央级公益性科研院所基本科研业务费项目:胸膜肺炎放线杆菌relA突变株的构建及其生物学特性研究(SKLVBP201418,2014.01-2014.12),10万元,主持;

7) 中央级公益性科研院所基本科研业务费项目:副猪嗜血杆菌细胞致死膨胀毒素CDT的致病机理研究(0302012014,2012.01-2013.12),10万元,主持;

8) 中央级公益性科研院所基本科研业务费项目:鸭疫里默氏杆菌毒力因子的鉴定及功能研究(SKLVBP201135,2011.01-2011.12),10万元,主持。

6、代表论文与著作

1) Tian Luan, Lu Wang, Jiyu Zhao, Hui Luan, Yueling Zhang, Chunlai Wang, Paul R. Langford, Siguo Liu, Wanjiang Zhang and Gang Li*. A CRISPR/Cas12a-assisted rapid detection platform by biosensing the apxIVA of  Actinobacillus pleuropneumoniae .  Frontiers in Microbiology . 2022,13: 928307

2) Guangjuan Gao, Dong Wei, Gang Li, Ping Chen, Liujun Wu, Siguo Liu, Yueling Zhang. Highly Effective Markerless Genetic Manipulation of Streptococcus suis Using a Mutated PheS-Based Counterselectable Marker.  Frontiers in Microbiology . 2022,13: 947821

3) Yue Jia, Changqi Hao, Qin Yang, Wanjiang Zhang, Gang Li, Siguo Liu, Xin Hua. Inhibition of  Haemophilus parasuis  by berberine and proteomic studies of its mechanism of action.  Research in Veterinary Science . 2021;138:62-68

4) Gang Li, Qian Zhao, Tian Luan, Yangbo Hu, Yueling Zhang, Ting Li, Chunlai Wang, Fang Xie, Wanjiang Zhang, Paul R. Langford, Siguo Liu*. Basal Level Effects of (p)ppGpp in the Absence of Branched Chain Amino Acids in  Actinobacillus pleuropneumoniae .  Journal of Bacteriology . 2020, 202:e00640-19

5) Ping Chen, Ran Liu, Mengmeng Huang, Jinlu Zhu, Dong Wei, Francis J Castellino, Guanghui Dang, Fang Xie, Gang Li, Ziyin Cui, Siguo Liu, Yueling Zhang. A unique combination of glycoside hydrolases in  Streptococcus suis  specifically and sequentially acts on host-derived αGal-epitope glycans.  Journal of Biological Chemistry . 2020, 295(31):10638-10652.

6) Gang Li, Fang Xie, Jianjun Li, Jiao Liu, Dapeng Li, Yanhe Zhang, Paul R. Langford, Yanwen Li, Siguo Liu, Chunlai Wang*. Identification of novel vaccine candidates of  Haemophilus parasuis  serovar 5 by immunoproteomics approach.  Journal of Proteomics . 2017, 163:111-117.

7) Gang Li, Hui Niu, Yanhe Zhang, Yanling Li, Fang Xie, Paul R. Langford, Siguo Liu, Chunlai Wang*. Haemophilus parasuis Cytolethal Distending Toxin Induces Cell Cycle Arrest and p53-dependent Apoptosis.  PLoS One . 2017, 12(5):e0177199.

8) Fang Xie, Gang Li, Long Zhou, Yanhe Zhang, Ning Cui, Siguo Liu, Chunlai Wang*. Attenuated  Actinobacillus pleuropneumoniae  double-deletion mutant S-8∆clpP/apxIIC confers protection against homologous or heterologous strain challenge.  BMC Veterinary Research.  2017, 13(1):14.

9) Fang Xie, Gang Li, Yalei Wang, Yanhe Zhang, Long Zhou, Chengcheng Wang, Shuanghong Liu, Siguo Liu, Chunlai Wang*. Pyridoxal phosphate synthases PdxS/PdxT are required for Actinobacillus pleuropneumoniae viability, stress tolerance and virulence.  PLoS One , 2017, 12(4): e0176374.

10) Fang Xie, Yalei Wang, Gang Li, Shuanghong Liu, Ning Cui, Siguo Liu, Paul R. Langford, Chunlai Wang. The SapA protein is involved in resistance to antimicrobial peptide PR-39 and virulence of Actinobacillus pleuropneumoniae.  Frontiers in Microbiology , 2017, 8:811.

11) Yanhe Zhang, Gang Li, Fang Xie, Siguo Liu, Chunlai Wang*. Evaluation of glutathione-binding protein A of  Haemophilus parasuis  as a vaccine candidate in a mouse model.  J Vet Med Sci , 2017, 79(1):184-187

12) Fang Xie, Gang Li, Yanhe Zhang, Long Zhou, Shuanghong Liu, Siguo Liu, Chunlai Wang*. The Lon protease homologue LonA, not LonC, contributes to the stress tolerance and biofilm formation of  Actinobacillus pleuropneumoniae.  Microb Pathog , 2016, 93:38-43.

13) Fang Xie, Gang Li, Yanhe Zhang, Long Zhou, Shuanghong Liu, Siguo Liu, Chunlai Wang*. Outer membrane lipoprotein VacJ is required for the membrane integrity and virulence of  Actinobacillus pleuropneumoniae.  Vet Microbiol , 2016, 183: 1-8.

14) Gang Li, Fang Xie, Yanhe Zhang, Janine T. Bossé2, Paul R. Langford, Chunlai Wang*. Role of (p)ppGpp in viability and biofilm formation of  Actinobacillus pleuropneumoniae .  PLoS One . 2015, (10): e0141501.

15) Mingming Hu, Yanhe Zhang, Fang Xie, Gang Li, Jianjun Li, Wei Si, Siguo Liu, Shouping Hu, Zhuo Zhang, Nan Shen, Chunlai Wang. Protection of Piglets by a  Haemophilus parasuis  Ghost Vaccine against Homologous Challenge.  Clinical and Vaccine Immunology . 2013, 20(6):795-802.

16) Fang Xie, Yanhe Zhang, Gang Li, Long Zhou, Siguo Liu, Chunlai Wang*. The ClpP Protease Is Required for the Stress Tolerance and Biofilm Formation in  Actinobacillus pleuropneumoniae .  PLoS One. 2013;8(1):e53600.

17) Gang Li, Fang Xie, Yanhe Zhang, and Chunlai Wang*. Draft genome sequence of  Actinobacillus pleuropneumoniae  serotype 7 strain S-8.  Journal of Bacteriology . 2012, 194(23):6606-6607.

18) Ming Liu, Chunguo Liu, Gang Li, Xiaojun Li, Xiuchen Yin, Yuhuan Chen, and Yun Zhang. Complete Genomic Sequence of Duck Flavivirus from China.  Journal of Virology . 2012. 86(6):3398-9.

19) Ming Liu, Shaoying Chen,Yuhuan Chen, Chunguo Liu, Shilong Chen, Xiuchen Yin, Gang Li, and Yun Zhang. Adapted Tembusu-Like Virus in Chickens and Geese in China.  Journal of Clinical Microbiology . 2012. 50(8):2807-9.

20) Gang Li, Yajian Song, Yanfen Xue, Lang Rao, Chen Zhou, Quanhui Wang, Yanhe Ma . Comparative proteome analysis of alkaliphilic  Bacillus  sp. N16-5 grown on different carbon sources.  Science China Life Science . 2011;54(1):90-100

21) Gang Li, Lang Rao, Yanfen Xue, Chen Zhou, Yun Zhang, Yanhe Ma. Cloning, expression, and characterization of a highly active alkaline pectate lyase from alkaliphilic  Bacillus sp. N16-5.  Journal of  Microbiological  Biotechnology . 2010, 20(4):670-7.

7、专利和标准

1) 李刚,张跃灵,王春来,刘思国。基于CRISPR-Cas12a的胸膜肺炎放线杆菌快速可视化检测方法,申请号:202011643292.2

2) 李刚,张跃灵,王春来,刘思国。一种基于CRISPR-Cas12a的猪链球菌快速可视化RPA检测试剂盒及其应用,申请号:202110863649.6

3) 李刚,王春来,张艳禾,谢芳。一种副猪嗜血杆菌免疫保护性抗原HbpA ZL 201310268864.7

4) 王春来,李刚,张艳禾,谢芳。一种副猪嗜血杆菌病亚单位疫苗组合物及应用 ZL 201310406551.3

5) 王春来,李刚,张艳禾,谢芳。一种副猪嗜血杆菌免疫保护性抗原OppA2 ZL 201310268810.0

6) 王春来,李刚,张艳禾,谢芳。一种副猪嗜血杆菌免疫保护性抗原AfuA ZL 201310268347.X

7) 王春来,李刚,张艳禾,谢芳。一种副猪嗜血杆菌免疫保护性抗原OppA ZL 201310268863.2

8) 王春来,张艳禾,李刚,谢芳。一种制备副猪嗜血杆菌病菌影疫苗的方法及其产品和应用 ZL 201310409237.0

8) 王春来,谢芳,李刚,张艳禾。一种不含抗性标记的猪胸膜肺炎弱毒活疫苗 ZL 201310469680.7

9) 谢芳,王春来,张艳禾,李刚。一种不含抗性标记的猪胸膜肺炎放线杆菌ClpP蛋白酶基因缺失株、其构建方法及应用 ZL 201110336861.3

8、获得奖励

1) 猪传染性胸膜肺炎菌影疫苗的研制及其应用,黑龙江省科技进步三等奖(王春来,李刚,谢芳,张艳禾,李艳玲,周泷),2017年。

2) 猪传染性胸膜肺炎菌影疫苗的研制及其应用,哈尔滨市科技进步二等奖(王春来,李刚,谢芳,张艳禾,李艳玲,周泷),2016年。


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