（2019年6月 网页更新）

1、个人简历

    王秀梅，女，博士，副研究员，硕士生导师，中国农业科学院哈尔滨兽医研究所动物支原体团队，中国畜牧兽医学会兽医药理与毒理学分会理事。主要从事动物源细菌耐药机制研究及动物支原体病诊断试剂、疫苗和防控技术的研究。目前主持国家自然基金等项目3项，参加其他省部级项目5项；发表SCI文章11篇，其中以第1作者发表SCI文章8篇，累计影响因子26；获得国家发明专利2项；参与指导毕业研究生4名，在读研究生2名。

2、联系方式    

（1）研究方向：兽医微生物及其分子生物学

（2）电话：0451-51051798, 15546385753

（3）邮箱：wangxiumei@caas.cn

（4）所在单位：中国农业科学院哈尔滨兽医研究所

（5）通讯地址：黑龙江省哈尔滨市香坊区哈平路678号

3、教育经历

2001.09-2005.06  河南农业大学  动物医学专业   学士

2005.09-2010.06  华南农业大学  动物医学专业   博士

4、工作经历

2010.07-2017.12   中国农业科学院哈尔滨兽医研究所   助理研究员

2018.01-至今  中国农业科学院哈尔滨兽医研究所   副研究员

5、承担项目

   1. 国家自然科学基金青年项目：AI-2/LuxS介导的QS系统调控禽肠炎沙门氏菌耐药性与致病力的研究（31402249，2015.1-2017.12），25万；

   2.  中央级公益性科研院所基本科研业务费专项：bla_NDM-1基因引起大肠杆菌耐药与适应性代价研究 （0302013014），2013.1-2014.12，20万；

    3. 兽医生物技术国家重点实验室自主研究课题: 猪肺炎支原体灭活疫苗研制(SKLVBP201806，201801-201912)，25万

6、代表论文与著作

      (1). Xiumei Wang, Yao Zhu, Xin Hua, Fuguang Chen, Changzhen Wang, Yanhe Zhang, Siguo Liu,Wanjiang Zhang*..F14:A-:B- and IncX4 Inc group cfr-positive plasmids circulating in Escherichia coli of animal origin in Northeast China. 2018, 217:53-57.

       (2). Xiu-Mei Wang, Zhimin Dong, Stefan Schwarz, Yao Zhu, Xin Hua,Yanhe Zhang,Siguo Liu,Wan-Jiang Zhang*. Plasmids of Diverse Inc Groups Disseminate the Fosfomycin Resistance Gene fosA3 among Escherichia coli Isolates from Pigs, Chickens, and Dairy Cows in Northeast China. Antimicrobial Agents and Chemotherapy, 2017,(59):7113-7116.

       (3). Wan-Jiang Zhang, Xiu-Mei Wang, Lei Dai, Xin Hua, Zhimin Dong, Stefan Schwarz, Siguo Liu*. Novel conjugative plasmid from Escherichia coli of swine origin that coharbors the multiresistance gene cfr and the extended-spectrum- β-lactamase gene bla_CTX-M-14b. Antimicrobial Agents and Chemotherapy, 2015,59(2):1337-1340. (first co-authors)

(4). Xiu-Mei Wang, Xing-Feng Lü, Lu Yin, Hui-Fang Liu, Wan-Jiang Zhang, Wei Si, Shen-Ye Yu , Mei-Li Shao, Si-Guo Liu*. Occurrence and antimicrobial susceptibility of Listeria monocytogenes isolates from retail raw foods. Food Control, 2013,32 (1):153-158.

(5). Xiu-Mei Wang, Wan-Jiang Zhang, Stefan Schwarz, Shen-ye Yu, Huifang Liu, Wei Si, Rong-Min Zhang, and Siguo Liu*. Methicillin-resistant Staphylococcus aureus ST9 from a case of bovine mastitis carries the genes cfr and erm(A) on a small plasmid. Journal of Antimicrobial Chemotherapy, 2012, 67(5):1287-1289.

(6). Bao-Tao Liu, Xiu-Mei Wang, Xiao-Ping Liao, Jian Sun, Heng-Qian Zhu, Xue-Ying Chen and Ya-Hong Liu*. Plasmid-mediated quinolone resistance determinants oqxAB, aac(6`)-Ib-cr and extended-spectrum β-lactamase gene bla_CTX-M-24 colocated on the same plasmid in one Escherichia coli strain from China. Journal of Antimicrobial Chemotherapy, 2011, 66 (7): 1638- 1639. (first co-authors)

(7). Xiu-Mei Wang, Xiao-Ping Liao, Si-Guo Liu, Wan-Jiang Zhang, Hong-Xia Jiang, Mei-Jun Zhang, Heng-Qian Zhu, Ying Sun, Jian Sun, Ai-Xin Li, Ya-Hong Liu*. Serotypes, virulence genes and antimicrobial susceptibility of Escherichia coli isolates from pigs. FEMS Microbiology Letters, 2010,306: 15-21.

(8). Xiu-Mei Wang, Xiao-Ping Liao, Wan-Jiang Zhang, Hong-Xia Jiang, Jian Sun, Mei-Jun Zhang,Xue-Fang He, Dong-Xing Lao, and Ya-Hong Liu*. Prevalence of Serogroups, Virulence Genotypes, Antimicrobial Resistance, and Phylogenetic Background of Avian Pathogenic Escherichia coli in South of China. Foodborne Pathogens Disease, 2010,7(9):1099-1106.

(9). Wei Si, Xiumei Wang, Huifang Liu, Shenye Yu, Zhaoli Li, Liping Chen, Wanjiang Zhang, Siguo Liu*. Physiology, pathogenicity and immunogenicity of live, attenuated Salmonella enterica serovar Enteritidis mutants in chicks. Microbial Pathogenesis, 2015,(83-84):6-11.

(10). Huifang Liu, Liping Chen, XiumeiWang,Wei Si, HuananWang, ChunlaiWang,Siguo Liu*, Guangxing Li*.Decrease of colonization in the chicks' cecum and internal organs of Salmonella enterica serovar Pullorum by deletion of cpdB by Red system. Microbial Pathogenesis,2015, 80:21-26.

(11). Hongbin Si, Wan-Jiang Zhang, Shengbo Chu, Xiu-Mei Wang, Lei Dai, Xin Hua,Zhimin Dong, Stefan Schwarz, Siguo Liu*. Novel Plasmid-Borne Multidrug Resistance Gene Cluster Including lsa(E) from a Linezolid-Resistant Enterococcus faecium Isolate of Swine Origin. Antimicrobial Agents and Chemotherapy, 2015, 59: 7113-7116.

7、专利和标准

    1.刘思国，刘慧芳，王秀梅，于申业，王牟平，司薇，杨志，减毒沙门氏菌及其应用,  ZL201110061628.9 

     2.刘思国，王秀梅，张万江，李兆利，一种含有凤尾草和磷霉素的畜禽用复方药物， ZL201410641161.9