刘永振-团队成员-中国农业科学院哈尔滨兽医研究所

1、个人简历

刘永振，男，博士，研究员，博士生导师。禽免疫抑制病研究团队骨干专家，中国农业科学院“青年英才”引进工程所级入选者。长期从事动物病毒学和细胞生物学相关领域的基础与应用基础研究，尤其是在禽疱疹病毒逃避宿主天然免疫反应机制、诱导宿主细胞代谢重塑等方面有较为突出的科研成果。在PNAS、mBio、PLoS Pathogens、JVI等学术期刊发表20余篇研究论文。其中以第一作者（含共同）在mBio、Plos Pathogens、JVI 等学术期刊发表SCI论文7篇。

2、联系方式

研究方向：兽医微生物及其分子生物学

电话：0451-51051692

电子邮箱：liuyongzhen@caas.cn

通讯地址：黑龙江省哈尔滨市香坊区哈平路678号

3、教育经历

2009.09-2013.06 青岛农业大学，动物医学专业，学士

2013.09-2019.07 中国农业科学院哈尔滨兽医研究所，预防兽医学，博士

4、工作经历

2019.08-2023.06 美国南加州大学，博士后

2023.07-今中国农业科学院哈尔滨兽医研究所，研究员

5、承担主要项目

1．农业生物育种重大项目子课题, 鸡马立克氏病病毒致病过程的分子机理研究（2023ZD0405303），2023.09-2025.12 ，100 万元，主持

2．黑龙江省留学回国人员择优资助（启动类），单细胞精度解析鸡胸腺发育的细胞图谱及鸡T细胞全谱系的形成，2023.11-2025.12，5 万元，主持

6、代表性论文

1. Liu Y^#, Qin C, Rao Y, Ngo C, Feng JJ, Zhao J, Zhang S, Wang TY, Carriere J, Savas AC, Zarinfar M, Rice S, Yang H, Yuan W, Camarero JA, Yu J, Chen XS, Zhang C, Feng P. SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response. mBio. 2021, 12(5): e0233521.

2. Li K^#, Liu Y^#, Xu Z, Zhang Y, Luo D, Gao Y, Qian Y, Bao C, Liu C, Zhang Y, Qi X, Cui H, Wang Y, Gao L, Wang X. Avian oncogenic herpesvirus antagonizes the cGAS-STING DNAsensing pathway to mediate immune evasion. PLoS Pathog. 2019, 15(9): e1007999.

3. Liu Y^#, Gao L^#, Xu Z, Luo D, Zhang Y, Gao Y, Liu C, Zhang Y, Qi X, Cui H, Li K, Wang X. Marek's Disease Virus RLORF4 Inhibits Type I Interferon Production by Antagonizing NFkappaB Activation. J Virol. 2019, 93(18): e01037-19.

4. Liu Y^#, Xu Z^# , Zhang Y, Yu M, Wang S, Gao Y, Liu C, Zhang Y, Gao L, Qi X, Cui H, Pan Q, Li K, Wang X. Marek's disease virus as a CRISPR/Cas9 delivery system to defend against avian leukosis virus infection in chickens. Vet Microbiol. 2020, 242:108589.

5. Li K^#, Liu Y^#, Xu Z, Zhang Y, Yao Y, Nair V, Liu C, Zhang Y, Gao Y, Qi X, Cui H, Gao L, Wang X. Prevention of Avian Retrovirus Infection in Chickens Using CRISPR-Cas9 Delivered by Marek's Disease Virus. Mol Ther Nucleic Acids. 2020, 21:343-353.

6. Liu Y^#, Li K^#, Cui H, Gao L, Liu C, Zhang Y, Gao Y, and Wang X. Comparison of different sites in recombinant Marek's disease virus for the expression of green fluorescent protein. Virus Res. 2017 May 2;235:82-85

7. Liu Y^#, Li K^#, Gao Y, Gao L, Zhong L, Zhang Y, Liu C, Zhang Y, and Wang X. Recombinant Marek's Disease Virus as a Vector Based Vaccine against Avian Leukosis Virus Subgroup J in Chicken. Viruses. 2016, 8(11):301.

8. Qin C, Rao Y, Yuan H, Wang TY, Zhao J, Espinosa B, Liu Y, Zhang S, Savas AC, Liu Q, Zarinfar M, Rice S, Henley J, Comai L, Graham NA, Chen C, Zhang C, Feng P. SARS-CoV-2 couples evasion of inflammatory response to activated nucleotide synthesis. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26): e2122897119.

9. Yun B, Zhang Y, Liu Y, Guan X, Wang Y, Qi X, Cui H, Liu C, Zhang Y, Gao H, Gao L, Li K, Gao Y, Wang X. TMPRSS12 Is an Activating Protease for Subtype B Avian Metapneumovirus. J Virol. 2016 Nov 28;90(24):11231-11246.

10. Gao L, Li K, Zhang Y, Liu Y, Liu C, Zhang Y, Gao Y, Qi X, Cui H, Wang Y, Wang X. Inhibition of DNA-Sensing Pathway by Marek's Disease Virus VP23 Protein through Suppression of Interferon Regulatory Factor 7 Activation. J Virol. 2019 Feb 5;93(4): e01934-18.